Clinical and Biological Signs of Dapagliflozin Overdose in ICU Patients With Metformin Poisoning

Recruiting now

Conditions studied: Drug Overdose, Metformin, Dapagliflozin, Lactic Acidosis, Diabetic Ketoacidosis, Intensive Care Units

In brief

This study looks at patients admitted to intensive care for drug poisoning involving metformin, a common diabetes medication. Researchers will compare two groups: patients who overdosed on metformin alone and those who took both metformin and dapagliflozin, another diabetes drug. The goal is to find clinical or laboratory signs that could help doctors quickly recognize a dapagliflozin overdose in this context, which could improve treatment and patient outcomes.

Key facts

Study ID

NCT07193069

Run by

Centre Hospitalier de Saint-Denis

People needed

50

Starts

2025-04-11

Expected to finish

2026-04-11

Last updated by the study team

2025-09-25

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults aged 18 years or older
• Admission to an intensive care unit (ICU) due to acute drug poisoning
• Documented exposure to either:
• Metformin alone
• Metformin in combination with dapagliflozin

You may not qualify if…

• Patients under 18 years of age
• No exposure to metformin
• Exposure to dapagliflozin without metformin

Where it is running

• Centre Hospitalier de Saint-Denis — Saint-Denis, France, France (enrolling)

Full record on ClinicalTrials.gov

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