Efficacy of an AFCN Proxy Block in Post-TKA Multimodal Pain Management
Starting soon · Not applicable · Has a placebo group
Conditions studied: Postoperative Pain Management in Total Knee Arthroplasty
In brief
This randomized controlled trial evaluates the additive effect of Supra-Sartorial Subcutaneous Infiltration (SSSI) when performed in combination with intermittent adductor canal block (iACB) and posterior capsule local infiltration analgesia (PC-LIA) for pain management after total knee arthroplasty (TKA). SSSI, an easy-to-perform tentative proxy block to targeted anterior femoral cutaneous nerve (AFCN) block, is tested in 90 adults (45-90 years) randomized into two arms: active SSSI versus sham SSSI. Primary outcome is pain scores at rest and during movement on postoperative day 0; secondary outcomes include daily pain trajectory at rest and during movement, functional recovery scores, rescue analgesic doses over days 0-3, and quality of recovery assessment on day 4.
Key facts
- Study ID
- NCT07191964
- Run by
- Taipei Medical University WanFang Hospital
- People needed
- 90
- Starts
- 2026-08-01
- Expected to finish
- 2027-09-01
- Last updated by the study team
- 2026-07-01
Who can join
Age: 45 and older, up to 90. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Adults aged 45-90 undergoing unilateral primary TKA for osteoarthritis.
- American Society of Anesthesiologists (ASA) physical status I-III.
- Able to provide informed consent and use NRS pain scales.
- Surgery scheduled to start before noon to standardize spinal anesthesia recovery.
You may not qualify if…
- Bilateral or revision TKA.
- Contraindications to regional anesthesia (e.g., coagulopathy, infection at injection site).
- Chronic opioid use (>30 mg morphine equivalents/day) or preoperative NRS >4.
- Pre-existing neurological deficits in lower extremities or AFCN-related neuropathy.
- Allergy to ropivacaine.
- Pregnancy, breastfeeding, or cognitive impairment affecting assessments.
Where it is running
- Taipei Municipal Wanfang Hospital — Taipei, Taiwan
Full record on ClinicalTrials.gov
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