Testing Personalized High-Definition Transcranial Direct Current Stimulation (HD-tDCS) as a Treatment of Posterior Cortical Atrophy
Recruiting now · Not applicable · Has a placebo group
Conditions studied: Posterior Cortical Atrophy
In brief
This study is being completed to learn if high-definition transcranial direct current stimulation (HD-tDCS) has an effect on visual and thinking abilities in persons with posterior cortical atrophy (PCA). Participants will be randomized to receive real or sham HD-tDCS (8 sessions over 4 days). Following the randomized treatment, participants will have optional open-label phase with real HD-tDCS up to 26 weeks and other possible testing.
Key facts
- Study ID
- NCT07191327
- Run by
- University of Michigan
- People needed
- 50
- Starts
- 2026-01-28
- Expected to finish
- 2029-07-31
- Last updated by the study team
- 2026-06-30
Who can join
Age: 50 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Diagnosis or symptoms consistent with PCA
- Fluent in English
- HD-tDCS compatible
- Stable on relevant medications for at least approximately 4 weeks prior to study enrollment
- If completing any additional, optional, long-term study visits in a remote location (i.e., not our office), a study partner is required in order to administer HD-tDCS. Those choosing to return to our office may have, but are not required to have, a study partner.
You may not qualify if…
- Other relevant neurological disease (e.g., epilepsy) or injuries (e.g., large vessel stroke, moderate-severe traumatic brain injury) viewed as primary to deficits since these could interfere with etiologic considerations and confound study results
- Active, relevant psychiatric conditions (e.g., bipolar disorder, schizophrenia) since the symptoms of these conditions may confound study participation.
- A recent (e.g., within the past 2 years) significant history of, or current, alcohol or drug abuse/dependence. Remote history of abuse/dependence is not exclusionary as long as it is not considered to be the primary etiology for visuospatial deficits.
- Women that are lactating/breastfeeding, pregnant, or may potentially be pregnant will be excluded from the study.
Where it is running
- University of Michigan — Ann Arbor, Michigan, United States (enrolling)
Full record on ClinicalTrials.gov
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