RESCUE: Discontinuation of GLP-1
Stopped early
Conditions studied: Obesity
In brief
This study is designed to compare weight loss outcomes and safety of ESG versus lifestyle modification in patients with obesity who discontinued GLP-1 therapy due to intolerance or suboptimal weight loss.
Key facts
- Study ID
- NCT07190794
- Run by
- Boston Scientific Corporation
- People needed
- 18
- Starts
- 2025-12-17
- Expected to finish
- 2026-05-26
- Last updated by the study team
- 2026-07-24
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Adults (≥ 18 years)
- BMI ≥30 kg/m² and ≤ 50 kg/m2
- Discontinued GLP-1 therapy for weight loss (semaglutide and tirzepatide only) for intolerance or suboptimal weight loss (<5% TBWL after 3 months at maximally tolerated dose)
- Initiation of weight loss management no earlier than August 2021
- Completed 1-year follow-up for weight loss management (ESG and lifestyle modification or lifestyle modification alone) following initiation of weight loss treatment
- Completed at least two interim visits for weight loss management from 1, 3, 6, through 9 months following initiation of weight loss treatment
You may not qualify if…
- Missing data regarding GLP-1 treatment history, including weight before GLP-1 treatment and at discontinuation, and discontinuation reason
- History of GLP-1 medication for a reason other than weight management
- Had bariatric surgery or an endoscopic procedure for weight loss treatment other than ESG with OverStitch™ or OverStitch NXT™ within 1 year of starting weight loss management
- Had an additional endoscopic treatment performed prior to or at the time of the ESG procedure that could influence weight loss results
- Had another weight loss treatment during the 1-year follow-up reported during this study. Weight loss treatment includes but is not limited to appetite suppressants, anti-obesity medications, plastic surgery or body contouring procedures.
- Pregnancy during the 1 year following initiation of weight loss management
Where it is running
- Bariendo — Miami, Florida, United States
Full record on ClinicalTrials.gov
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