Prilocaine for Sphenopalatine Ganglion Block in Endoscopic Hypophysectomy

Recruiting now · Not applicable

Conditions studied: Blood Pressure Control

In brief

Patients undergoing endoscopic surgeries for pituitary adenoma excision suffer from wide swings in blood pressure that might increase bleeding and interfere with the surgical field. Local anethetic infiltration and regional nerve blocks have been used to provide better analgesia, control blood pressure and improve surgical field. Limited studies evaluated shenopalatine ganglion block in pituitary adenoma excision with promising outcomes. The proposed study will compare the efficacy of two local anesthetics, prilocaine and lidocaine, for spenopalatine ganglion block in patients undergoing endoscopic pituitary adenoma excision. Evaluating the control of the intraoperative blood pressure and analgesic sparing are the main objectives of the proposed study.

Key facts

Study ID

NCT07188987

Run by

Kasr El Aini Hospital

People needed

54

Starts

2025-12-01

Expected to finish

2026-02-01

Last updated by the study team

2025-12-05

Who can join

Age: 21 and older, up to 45. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with pituitary adenoma undergoing endoscopic hypophysectomy.
• ASA physical status I and II.
• Age above 21, below 45 years.
• Male or female

You may not qualify if…

• Any patient below 21 years or above 45 years.
• Patients suffering from any of the following conditions:
• Disturbed conscious level.
• Coagulation abnormalities.
• Poorly controlled blood pressure and/or heart rate.
• Increased intracranial tension.
• Liver and kidney disorders.
• Patients on anticoagulants and/or NSAIDS (non-steroidal anti- inflammatory drugs
• Patients addicted to drugs and/or alcohol.
• Patients with disturbed conscious level at the end of the surgery, GCS >14

Where it is running

• Kasr El Ainy — Cairo, Egypt (enrolling)

Full record on ClinicalTrials.gov

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