A Study to Investigate Ronde-cel Versus Investigator's Choice CD19 CAR T-Cell Therapy

Recruiting now · Phase 3

Conditions studied: Large B-cell Lymphoma, Lymphoma, B-Cell, Relapsed Non-Hodgkin Lymphoma, Refractory Non-Hodgkin Lymphoma, Non-Hodgkin Lymphoma, Non-Hodgkin Lymphoma Refractory/ Relapsed, Diffuse Large B Cell Lymphoma (DLBCL), Diffuse Large B Cell Lymphoma Refractory, Diffuse Large B Cell Lymphoma Relapsed

In brief

This Phase 3 study compares rondecabtagene autoleucel (ronde-cel), a dual-targeting CD19/CD20 CAR T-cell therapy, with investigator's choice of CD19 CAR T-cell therapy in patients with relapsed or refractory large B-cell lymphoma in the second-line setting.

Key facts

Study ID

NCT07188558

Run by

Lyell Immunopharma, Inc.

People needed

400

Starts

2026-01-12

Expected to finish

2032-01-01

Last updated by the study team

2026-08-04

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Virginia Oncology Associates — Norfolk, Virginia, United States (enrolling)
• Honor Health — Scottsdale, Arizona, United States (enrolling)
• Mayo Clinic Arizona — Scottsdale, Arizona, United States (enrolling)
• Duke Cancer Institute — Durham, North Carolina, United States (enrolling)
• Oncology Hematology Care Clinical Trials — Cincinnati, Ohio, United States (enrolling)
• University of Cincinnati — Cincinnati, Ohio, United States (enrolling)
• SCRI Oncology Partners — Nashville, Tennessee, United States (enrolling)
• St. David's South Austin Medical Center — Austin, Texas, United States (enrolling)
• MD Anderson Cancer Center — Houston, Texas, United States (enrolling)
• Texas Transplant Institute — San Antonio, Texas, United States (enrolling)
• Intermountain Healthcare — Salt Lake City, Utah, United States (enrolling)
• Banner MD Anderson Cancer Center — Gilbert, Arizona, United States (enrolling)
• Cedars-Sinai Medical Center — Los Angeles, California, United States (enrolling)
• University of California, Los Angeles (UCLA) — Los Angeles, California, United States (enrolling)
• University of California, Irvine — Orange, California, United States (enrolling)
• University of Colorado — Aurora, Colorado, United States (enrolling)
• Colorado Blood Cancer Institute — Denver, Colorado, United States (enrolling)
• Mayo Clinic Florida — Jacksonville, Florida, United States (enrolling)
• Moffitt Cancer Center — Tampa, Florida, United States (enrolling)
• Northside Hospital — Atlanta, Georgia, United States (enrolling)
• University of Chicago — Chicago, Illinois, United States (enrolling)
• University of Kansas Cancer Center — Westwood, Kansas, United States (enrolling)
• University of Louisville Health — Louisville, Kentucky, United States (enrolling)
• Mayo Clinic Rochester — Rochester, Minnesota, United States (enrolling)
• University of Nebraska Medical Center (UNMC) — Omaha, Nebraska, United States (enrolling)

Full record on ClinicalTrials.gov

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