A Study Looking at a New Nerve Surgery to Help Men Regain Erections After Prostate Cancer Surgery

Recruiting now · Not applicable

Conditions studied: Prostate Cancer, Erectile Dysfunction Following Radical Prostatectomy

In brief

A single arm prospective pilot trial evaluating the 1-year erectile recovery outcomes and the safety of patients undergoing a somatic to autonomic nerve grafting procedure for restoration of erectile function in patients who have lost erectile function following radical prostatectomy for prostate cancer. During this study a total of 100 patients who have persistent erectile dysfunction for more than 18 months post prostatectomy will undergo a post radical prostatectomy nerve restoration procedure (PRP-NR).

Key facts

Study ID

NCT07188064

Run by

Sir Mortimer B. Davis - Jewish General Hospital

People needed

100

Starts

2026-01-30

Expected to finish

2028-12-01

Last updated by the study team

2026-03-10

Who can join

Age: 18 and older. Sex: male. Healthy volunteers: not accepted.

You may qualify if…

• Patients with persistent post prostatectomy erectile dysfunction as defined below:
• Severe ED (IIEF score 5-7) and more than 12 months from prostatectomy OR
• Moderate ED (IIEF score 8-11) and more than 18 months from prostatectomy
• Patients must have had good pre-prostatectomy erectile function with a baseline IIEF score of ≥17 on self-reported assessment of historic function.

You may not qualify if…

• Patients aged < 18 years at diagnosis
• Legally incapable patients
• Patients >5 years from prostatectomy.
• Bilateral open inguinal hernia repair
• Patients with pre-existing significant neurologic disease
• Diabetes with evidence of peripheral nerve involvement and end organ dysfunction
• Coronary artery disease with unstable angina
• Mood disorder (anxiety/depression) with change in medical therapy within last 3 months
• Pre-existing penile base surgery which would prevent grafting technique including suprapubic liposuction, suspensory ligament release
• Pre-existing penile prosthesis
• Current use of androgen deprivation therapy
• Use of medications for chronic nerve pain (gabapentin, amitriptyline, nortriptyline, pregablin)
• Previous untreated penile trauma
• Patients deemed medically unfit for surgery

Where it is running

• Jewish General Hospital — Montreal, Quebec, Canada (enrolling)

Full record on ClinicalTrials.gov

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