Evaluating the Clinical Efficacy of Thulio vs. Holmium Laser Enucleation of the Prostate

Recruiting now · Not applicable

Conditions studied: BPH With Symptomatic Lower Urinary Tract Symptoms, BPH With Urinary Obstruction

In brief

Many consider laser enucleation of the prostate the new 'gold standard' for the surgical treatment of benign prostatic hyperplasia (BPH) due to its excellent outcomes, high success rates, and long-term efficacy. Holmium laser enucleation of the prostate (HoLEP) was the earliest form of prostate enucleation and is recommended by the American Urological Association (AUA), along with thulium laser enucleation of the prostate (ThuLEP), as size-independent techniques for the management of BPH with fewer complications than transurethral resection of the prostate (TURP). Further development of laser technology has additionally led to enucleation using pulsed-modulated (e.g. "Virtual Basket™" mode or MOSES™ mode) holmium lasers as well as the thulium fiber laser.

Key facts

Study ID

NCT07187180

Run by

Smita De

People needed

50

Starts

2025-06-02

Expected to finish

2026-09-01

Last updated by the study team

2025-09-22

Who can join

Age: 18 and older. Sex: male. Healthy volunteers: accepted.

You may qualify if…

• Understand and voluntarily sign an informed consent form.
• Patients must be males with a prostate, at least 18 years of age
• No prior prostate surgery

You may not qualify if…

• Unable/refuse to provide informed consent
• Prior prostate surgery
• Bladder stones that requiring lasering (small stone that can be removed whole is ok)
• Unable to hold anticoagulants or antiplatelets per standard protocols for surgery and up to 1 week postop.

Where it is running

• Cleveland Clinic Main — Cleveland, Ohio, United States (enrolling)

Full record on ClinicalTrials.gov

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