A Clinical Trial to Test if the Investigational Drug BNT329 is Safe and Potentially Beneficial for People With Advanced Solid Tumors Known to Express the Tumor Marker CA19-9
Recruiting now · Phase 1/Phase 2
Conditions studied: Advanced Solid Cancers
In brief
The main goal of this study is to evaluate the safety of BNT329 and to identify the best dose of BNT329. This will be done by measuring the number of side effects that participants experience and how severe they are. The second goal of this study is to evaluate how well BNT329 works. This will be done by measuring the number of participants who respond to the treatment. The length of time where the tumor does not grow or spread will also be measured. The study will also evaluate how BNT329 moves into, through, and out of the body and how the treatment affects the body.
Key facts
- Study ID
- NCT07186842
- Run by
- BioNTech SE
- People needed
- 245
- Starts
- 2025-11-18
- Expected to finish
- 2030-05-01
- Last updated by the study team
- 2026-07-17
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- SCRI at HCA Health One — Denver, Colorado, United States (enrolling)
- Florida Cancer Specialists — Orlando, Florida, United States (enrolling)
- Memorial Sloan Kettering Cancer Center — New York, New York, United States (enrolling)
- Monash Health — Clayton, Australia (enrolling)
- Austin Health — Heidelberg, Australia (enrolling)
- St. Josef-Hospital im Katholischen Klinikum Bochum — Bochum, Germany (enrolling)
- Universitaetsklinikum Ulm — Ulm, Germany (enrolling)
- Hospital Universitari Vall d'Hebron — Barcelona, Spain (enrolling)
- Hospital San Pedro — Logroño, Spain (enrolling)
- Hospital Universitario HM Sanchinarro - START Madrid CIOCC — Madrid, Spain (enrolling)
- Hospital Universitario Quironsalud Madrid - NEXT Oncology — Pozuelo de Alarcón, Spain (enrolling)
- St James´s University Hospital — Leeds, United Kingdom (enrolling)
- Royal Free Hospital — London, United Kingdom (enrolling)
- The Christie NHS Foundation Trust — Manchester, United Kingdom (enrolling)
- Northern Centre for Cancer Research — Newcastle upon Tyne, United Kingdom (enrolling)
- The Royal Marsden Hospital — Sutton, United Kingdom (enrolling)
Full record on ClinicalTrials.gov
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