Virtual tES Device Treatment for Parkinson's Disease Motor Symptoms

Recruiting now · Phase 1/Phase 2 · Has a placebo group

Conditions studied: PARKINSON DISEASE (Disorder)

In brief

This study tests a new, non-invasive brain stimulation device called Sphere V3.0 to help improve movement problems in people with Parkinson's disease. The device delivers gentle electrical signals to the scalp using small electrodes placed on the head. Participants will use the device at home for 13 minutes each weekday (Monday through Friday) for 3 weeks, then be monitored for another 3 weeks without treatment. The entire study lasts 6 weeks and is conducted virtually through video calls and online assessments. The investigators will measure changes in Parkinson's symptoms using standard rating scales and video recordings of movement tasks like walking and hand tremor tests. Participants will also record videos of their movements at home using their smartphone or computer. The study includes 30 adults aged 18-80 who have been diagnosed with Parkinson's disease and have stable medication for at least 4 weeks. Participants must have reliable internet access and be able to follow the treatment schedule. The main goal is to see if this brain stimulation treatment can reduce motor symptoms like tremor, stiffness, and slowness of movement. The investigators will also check if any improvements last after treatment ends and monitor for any side effects. All participants receive the active device treatment - there is no placebo group. The device has been tested in over 250 people in previous studies with no serious adverse events reported

Key facts

Study ID

NCT07182058

Run by

U: The Mind Company

People needed

30

Starts

2026-01-01

Expected to finish

2026-04-01

Last updated by the study team

2026-01-27

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults 18-80 years with confirmed diagnosis of Parkinson's Disease
• Hoehn \& Yahr stages 1-4
• Stable medication regimen for 4+ weeks prior to enrollment
• Reliable internet access and telehealth capability
• Ability to provide informed consent
• Willingness to comply with treatment protocols and follow-up procedures

You may not qualify if…

• Metallic head/neck implants (excluding dental fillings)
• Pregnancy or nursing status
• Severe skin conditions at electrode placement sites
• History of epilepsy or seizures (unless technology specifically indicated)
• Recent stroke or traumatic brain injury (within 6 months)
• Severe cognitive impairment preventing treatment understanding
• Any neurological disorders contraindicating transcranial electrical stimulation
• Current participation in other clinical trials
• Inability to commit to full treatment and follow-up schedule

Where it is running

• U LLC Headquarters — Cleveland, Ohio, United States (enrolling)

Full record on ClinicalTrials.gov

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