Ketamine in Central Sensitization

Withdrawn before enrolling · Phase 4

Conditions studied: Endometriosis, Chronic Pelvic Pain

In brief

The purpose of this research study is to see if ketamine infusion during surgery can decrease pain after surgery. Ketamine is a medication commonly used as part of anesthesia during surgery and is approved by the US FDA. Patients will be randomized to either receive standard anesthesia with OR without ketamine. The surgical procedure will be the same regardless of which group patients are randomized to. After surgery, patients will be asked to rate their pain in the post-operative observation unit and at their two-week post-operative visit. No additional visits are required for participation in this study. The investigators estimate the surveys will take approximately 10 minutes to complete.

Key facts

Study ID

NCT07182032

Run by

University Hospitals Cleveland Medical Center

People needed

0

Starts

2026-02-01

Expected to finish

2028-06-30

Last updated by the study team

2026-05-11

Who can join

Age: 18 and older, up to 89. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• age range 18-89
• ASA classification I-III
• outpatient elective laparoscopy for endometriosis

You may not qualify if…

• known allergy or contraindication to ketamine
• History of substance use disorder, including alcohol or marijuana use, both current and remote
• History of severe psychiatric illness, including schizoaffective disorder, bipolar disorder, psychosis, or decompensated psychiatric condition , excluding anxiety and depression
• Current Intraoperative complications

Where it is running

• University Hospitals Cleveland Medical Center — Cleveland, Ohio, United States

Full record on ClinicalTrials.gov

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