Quantitative and Qualitative Monocytes Analysis and Their Impact on CART Cells Reponse in Multiple Myeloma

Recruiting now

Conditions studied: Multiple Myeloma, Monocytes, CART Cells

In brief

Tumoral micro-environment in malignant haematological diseases, notably in multiple myeloma, is active on plasma cells survival and proliferation. Monocytosis and monocytes typing are described in multiple myeloma response as factors on proliferation and cell death evasion. CART cells have improved multiple myeloma care in last 5 years, nethertheless, early relapse occur and we must identify predictor factors of better response. The aim of this study is to analyze basic level and phenotyping of monocytes before and after CART cells infusion and study their impact on multiple myeloma response

Key facts

Study ID

NCT07180992

Run by

Centre Hospitalier Universitaire, Amiens

People needed

25

Starts

2025-07-16

Expected to finish

2028-09-01

Last updated by the study team

2025-11-18

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients over 18 years old
• Treated for a multiple myeloma
• CART cells treatment proposed
• Affiliated to social security system
• Agreed to participate to the study

Where it is running

• CHRU Amiens — Amiens, France (enrolling)

Full record on ClinicalTrials.gov

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