Comparison of Perineural Dexamethasone Versus Dexmedetomidine as Adjuvants to Erector Spinae Plane Block in Lumbar Spine Surgery: A Randomized, Double-blind, Controlled Trial

Recruiting now · Phase 4

Conditions studied: Spine Disease, Spinal Diseases

In brief

This clinical study aims to determine which of two medications-dexamethasone or dexmedetomidine-works better and is safer when used together with a local anesthetic (ropivacaine) in a type of nerve block called the erector spinae plane block (ESPB). This block helps reduce pain after lumbar spine surgery.

Key facts

Study ID

NCT07180940

Run by

Poznan University of Medical Sciences

People needed

150

Starts

2025-09-01

Expected to finish

2026-12-31

Last updated by the study team

2025-09-18

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults aged 18 to N/A (no limit)
• Scheduled for elective lumbar spine surgery (e.g., decompression or fusion) via posterior approach
• American Society of Anesthesiologists (ASA) physical status I-III
• Body weight ≥ 50 kg
• Ability to provide written informed consent
• Expected postoperative hospitalization of at least 48 hours

You may not qualify if…

• Known allergy or contraindication to ropivacaine, dexamethasone, or dexmedetomidine
• Infection at or near the site of block placement
• Coagulation disorders or current use of anticoagulant therapy (not discontinued per guidelines)
• Chronic opioid use or opioid dependence
• Neurological or psychiatric disorders interfering with pain assessment
• Diabetes mellitus with poorly controlled glycemia (e.g., HbA1c > 8%)
• Severe hepatic or renal dysfunction
• Body mass index (BMI) > 40 kg/m²
• Pregnancy or breastfeeding
• Refusal or inability to cooperate with the study protocol

Where it is running

• Poznan University of Medical Sciences — Poznan, Poland (enrolling)

Full record on ClinicalTrials.gov

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