Remote Ischaemic Conditioning in the Older Person and Effects on Dynamic Cerebral Autoregulation
Recruiting now · Not applicable · Has a placebo group
Conditions studied: Cerebral Autoregulation, Blood Pressure, Dynamic Cerebral Autoregulation
In brief
Remote Ischaemic Conditioning (RIC) is the process of inducing short periods of ischaemia in a limb with the aim of improving vascular health systemically. Recent findings have demonsatrated efficacy in a variety of clinical settings. However, the ideal protocol of RIC \[dose\] is unknown. Dynamic Cerebral Autoregulation (dCA) has been shown to increase in response to RIC. The goal of this trial is to study whether an increase in RIC protocol intensity results in a larger effect on biomarkers of vascular health such as dCA. Participants shall: Receive RIC daily, RIC thrice weekly or sham RIC thrice weekly for 6 weeks Visit the School of Medicine at baseline and at 6 weeks for measurement of biomarkers of vascular health including blood pressure, indices od dCA and blood plasma samples
Key facts
- Study ID
- NCT07179887
- Run by
- University of Nottingham
- People needed
- 45
- Starts
- 2025-08-27
- Expected to finish
- 2027-09-30
- Last updated by the study team
- 2025-09-18
Who can join
Age: 65 and older, up to 85. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Participant is willing and able to give informed consent for participation in the study
- Participant aged 65 - 85
- Participant is able to perform RIC independently at home
You may not qualify if…
- Active cardiovascular or cerebrovascular disease (acute event within the last 12 months)
- Atrial fibrillation or other significant arrhythmias
- Peripheral Vascular Disease
- Haemostatic disorders
- Soft tissue injury or fracture to the upper limb
- Pregnant or breast feeding
- History or current psychiatric illness
- History or current neurological condition (e.g. epilepsy)
- Inability to identify temporal window for transcranial doppler ultrasound at screening visit
- Any condition or presentation under current investigation that is deemed by the study clinician to exclude the participant from the study.
- Having taken part in a research study in the last 3 months involving invasive procedures or an inconvenience allowance
Where it is running
- School of Medicine, University of Nottingham, Royal Derby Hospital Centre — Derby, Derbyshire, United Kingdom (enrolling)
Full record on ClinicalTrials.gov
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