Clinical Outcomes and Quality of Life in Patients With Locally Advanced Vulvovaginal Cancers: Ambispective Registration Study.

Recruiting now

Conditions studied: Vulvo-vaginal Cancer

In brief

The vaginal cancers are responsible for 2% of gynecological cancer while vulvar cancers account for 4 % of gynecological cancers. HPV 16 and 33 are most prevalent in vaginal cancers and account for more than half of cases HPV related vaginal cancer. However, adeqaute information is not there. Similarly, structured QOL data is not available for India. Therefore, in the proposed study we will like to systematically evaluate the patterns of relapse and disease outcomes in patients with vulvovaginal cancer treated with radiation (+/- chemotherapy). The therapeutic research in vulvo-vaginal cancers has been relatively slow and such structured registration databases can allow analysis of large number of patients to report on acute and late effect of treatment outcomes using CTCAE and QOL (EORTC QLQ C-30 and VU-34) in rare cancers. We hope that we will get help in identifying thrust areas for future research including prospective interventional trials through this study.

Key facts

Study ID

NCT07179757

Run by

Tata Memorial Hospital

People needed

200

Starts

2021-10-30

Expected to finish

2026-10-01

Last updated by the study team

2026-02-04

Who can join

Age: any. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• All patients diagnosed with vulvo- vaginal cancer.
• Patients treated with Radiation+/- chemotherapy+/-surgery from January 1, 2019- December 31, 2023.

You may not qualify if…

• Patients with Metastatic disease at the presentation.
• Incomplete information on the EMR.

Where it is running

• Tata Memorial Hospital — Mumbai, Maharashtra, India (enrolling)

Full record on ClinicalTrials.gov

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