Low Serum Creatinine as a Predictor of Prolonged Mechanical Ventilation and Weaning Failure

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Prolonged Mechanical Ventilation, Critical Illness

In brief

The main objective of the study is to determine whether a subnormal serum creatinine value upon admission to the Post-ICU Care Unit predicts the need for prolonged ventilatory support. A parallel objective of the study is to determine whether exogenous in-take of the dietary supplement creatine in patients with subnormal serum creatinine value is associated with a shortened duration of ventilatory support and improved patients outcome.

Key facts

Study ID

NCT07177183

Run by

University Hospital Ostrava

People needed

492

Starts

2026-02-02

Expected to finish

2028-02-02

Last updated by the study team

2026-02-05

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients <18 years of age
• Patients admitted to post-ICU care units at Chronicare Group a.s. in the Czech Republic within 12 months

You may not qualify if…

• Patients who are unlikely to be weaned from ventilatory support.
• Patients in palliative care or with a survival probability of <3 months
• Patients with advanced malignancy
• Patients with a history of chronic kidney disease
• Patients with a history of chronic liver disease
• Patients with supranormal serum creatinine on admission to the post-ICU care unit
• Patients who refused to sign the Informed Consent with participation in the study.

Where it is running

• Chronicare Mund s.r.o. — Brno, Czechia (enrolling)
• Chronicare s.r.o. — Milovice, Czechia (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.