Exploring Blood Cell Function and Oxidative Stress to Improve Diagnosis and Treatment in Pre-Capillary Pulmonary Hypertension

Recruiting now

Conditions studied: Pre-capillary Pulmonary Hypertension

In brief

This study aims to understand how blood cell (including peripheral blood mononuclear cells ((PBMCs) or platelets) function and oxidative stress can help physicians detect and predict the course of pre-capillary pulmonary hypertension. We hypothesize that changes in the mitochondrial function of blood cells and oxidative stress may be early markers of disease progression and severity. The study will also explore how these blood markers relate to routine clinical and heart function measurements, such as echocardiography, right heart catheterization, 6-minute walk tests, and functional status, to see if they can help monitor patients over time and guide personalized care. This is a non-interventional study. Blood samples will be collected during routine visits planned for diagnosis and follow-up. The study will include 120 patients diagnosed with pre-capillary pulmonary hypertension, who will be followed for 3 years. Blood samples will be taken up to three times per year to measure mainly oxidative stress and mitochondrial function in blood cells. These measurements will be compared with clinical tests to see if they can help predict the course of the disease.

Key facts

Study ID

NCT07176260

Run by

University Hospital, Strasbourg, France

People needed

120

Starts

2025-09-01

Expected to finish

2026-06-01

Last updated by the study team

2025-09-16

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult patients (≥18 years) diagnosed with pre-capillary pulmonary hypertension confirmed by right heart catheterization
• Patients classified according to the international clinical classification:
• Group 1: Pulmonary arterial hypertension (PAH)
• Group 3: Pulmonary hypertension associated with chronic respiratory diseases and/or hypoxia
• Group 4: Chronic thromboembolic pulmonary hypertension (CTEPH)
• Patients scheduled for routine clinical follow-up and/or right heart catheterization at the study center.
• Ability and willingness to provide informed consent for participation and data analysis.

You may not qualify if…

• Postcapillary pulmonary hypertension (pulmonary arterial wedge pressure >15 mmHg).
• Conditions precluding safe blood sampling (e.g., severe anemia, coagulopathy).
• Patients already enrolled in interventional clinical trials that could interfere with mitochondrial or oxidative stress measurements
• Patients unable or unwilling to provide informed consent
• Pregnancy or breastfeeding

Where it is running

• Hôpitaux Universitaires de Strasbourg - Service Physiologie explorations fonctionnelles — Strasbourg, Bas-Rhin, France (enrolling)

Full record on ClinicalTrials.gov

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