Safety in Adult Participants With Atrial Fibrillation Who Are Treated With Anticoagulation
Recruiting now · Phase 2
Conditions studied: Atrial Fibrillation (AF)
In brief
This study is researching experimental drugs called REGN7508 and REGN9933. The study is focused on participants who have atrial fibrillation, which means that the heart beats too fast and unevenly. REGN7508 and REGN9933 are designed to help stop blood clots forming in patients with atrial fibrillation. The aim of the study is to see how well REGN7508 and REGN9933 work in patients that get medicine for their atrial fibrillation. The bleeding effects of REGN7508 and REGN9933 will be compared to another medicine (apixaban), which is available on the market to treat and prevent formation of blood clots. The study is looking at several other research questions, including: * What side effects may happen from taking REGN7508 or REGN9933 * How well do the study drugs reduce the risk of having a stroke * How much of REGN7508 or REGN9933 is in the blood at different times * Whether the body makes antibodies against REGN7508 or REGN9933 (which could make the drugs less effective or could lead to side effects)
Key facts
- Study ID
- NCT07175428
- Run by
- Regeneron Pharmaceuticals
- People needed
- 1200
- Starts
- 2025-10-20
- Expected to finish
- 2027-04-21
- Last updated by the study team
- 2026-08-05
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- SEC Clinical Research — Dothan, Alabama, United States (enrolling)
- Valley Clinical Trials, Inc — Covina, California, United States (enrolling)
- Eastern Shore Research Institute — Fairhope, Alabama, United States (enrolling)
- Mission Cardiovascular Research Institute — Fremont, California, United States (enrolling)
- National Institute of California Heart and Vein Specialists — Huntington Beach, California, United States (enrolling)
- Profound Research LLC at Southern California Heart Specialists — Pasadena, California, United States (enrolling)
- Empire Clinical Research — Pomona, California, United States (enrolling)
- North Coast Cardiology — Encinitas, California, United States (enrolling)
- Cardiology Associates Medical Group — Ventura, California, United States (enrolling)
- Interventional Cardiology Medical Group — West Hills, California, United States (enrolling)
- Nouvelle Clinical Research LLC — Cutler Bay, Florida, United States (enrolling)
- South Florida Research Organization LLC — Medley, Florida, United States (enrolling)
- Inpatient Research Clinic LLC — Miami Lakes, Florida, United States (enrolling)
- Cardiovascular Center of Sarasota Foundation for Research and Education — Sarasota, Florida, United States (enrolling)
- Clinical Site Partners, LLC DBA Flourish Research — Winter Park, Florida, United States (enrolling)
- Grady Health System — Atlanta, Georgia, United States (enrolling)
- Northbay Clinical Research Center — Santa Rosa, California, United States (enrolling)
- NSC Research, Inc — Johns Creek, Georgia, United States (enrolling)
- Indiana University — Indianapolis, Indiana, United States (enrolling)
- Blue Coast Research Center, LLC — Indianapolis, Indiana, United States (enrolling)
- Franciscan Physician Network, Indiana Heart Physicians — Indianapolis, Indiana, United States (enrolling)
- Indiana Medical Research — Merrillville, Indiana, United States (enrolling)
- Reid Physician Associates — Richmond, Indiana, United States (enrolling)
- Monroe Research, LLC — West Monroe, Louisiana, United States (enrolling)
- Anderson Medical Research — Ft. Washington, Maryland, United States (enrolling)
Full record on ClinicalTrials.gov
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