Early Double Sequential Defibrillation in Out of Hospital Cardiac Arrest
Recruiting now · Phase 2/Phase 3
Conditions studied: Out of Hospital Cardiac Arrest, Ventricular Fibrillation, Defibrillation, CPR, ACLS, Sudden Death
In brief
Some of the patients affected by Out-of-hospital cardiac arrest (OHCA) with ventricular fibrillation (VF)/ventricular tachycardia (VT) do not respond to initial defibrillation. The survival decreases with number of defibrillations required to terminate VF/VT. In 2022, one prospective cluster randomized trial showed increased survival among (OHCA) patients in refractory VF using Double Sequential Defibrillation (DSD). If DSD can increase survival among all patients in VF that dont respond to one defibrillation, i.e. before it has become refractory is not known. The aim of this trial is to assess survival with a double defibrillation strategy initiated as soon as possible among patients with Out of Hospital Cardiac Arrest with initial shockable rhythm and at least one failed standard defibrillation, compared with continued resuscitation using standard defibrillation.
Key facts
- Study ID
- NCT07174986
- Run by
- Gabriel Riva
- People needed
- 916
- Starts
- 2025-09-08
- Expected to finish
- 2029-12-01
- Last updated by the study team
- 2026-02-17
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- OHCA patients with VT/VF at first rhythm analysis and at least one defibrillation performed in standard (A-L) position
You may not qualify if…
- Age < 18 years
- Obvious pregnancy
- Known preexisting Do Not Attempt Resuscitation order
Where it is running
- Emergency medical services NU-Sjukvården, Region Västra Götaland — Trollhättan, Sweden (enrolling)
- Sjukvården i väster — Alingsås, Sweden (enrolling)
- Emergency medical services, Södra Älvsborgs Sjukhus, Region Västra Götaland — Borås, Sweden (enrolling)
- Prehospital Intensive Care Unit (PIV) AnOPIVA Östra Sjukhuset/SU — Gothenburg, Sweden (enrolling)
- Shalgrenska University Hospital — Gothenburg, Sweden (enrolling)
- Ambulanssjukvården Skaraborgs Sjukhus, Västra Götalandsregionen (SKAS) — Skövde, Sweden (enrolling)
- Ambulanssjukvården, Region Halland — Halmstad, Halland County, Sweden (enrolling)
- Ambulanssjukvården Region Värmland — Karlstad, Värmland County, Sweden (enrolling)
- Ambulanshelikoptern (HEMS) Västra Götalandsregionen — Kungälv, Västra Götaland County, Sweden (enrolling)
- Centro de Emergencias 061 Andalucía — Málaga, Andalusia, Spain
- Médico Emergencias Osakidetza EMERGENTZIAK — Bilbao, Baque Country, Spain
- Sistema de Emergencias Medicas de Catalunya — Barcelona, Catalonia, Spain
- SUMMA 112 Emergency medical services — Madrid, Madrid, Spain
- ARREST (AmsteRdam REsuscitation STudies) — Amsterdam, Netherlands
Full record on ClinicalTrials.gov
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