Post-hysterectomy Vaginal Cuff Prolapse Repair
Recruiting now · Not applicable
Conditions studied: Vaginal Cuff Complications
In brief
This study is a randomized controlled trial comparing two minimally invasive surgeries-laparoscopic lateral suspension and laparoscopic sacrocolporopexy-for women who develop vaginal cuff prolapse after hysterectomy. Vaginal cuff prolapse occurs when the top of the vagina loses support after the uterus is removed, which can cause discomfort, bulging, or urinary and bowel problems. The goal of this study is to determine which surgical approach is safer, more effective, and improves quality of life for patients. Women enrolled in the trial will be randomly assigned to one of the two surgeries, and outcomes such as prolapse recurrence, complications, recovery time, and patient satisfaction will be carefully monitored. By comparing these two techniques, this study aims to provide clear guidance for surgeons and patients to make informed decisions about the best surgical treatment for post-hysterectomy vaginal cuff prolapse.
Key facts
- Study ID
- NCT07174921
- Run by
- Kanuni Sultan Suleyman Training and Research Hospital
- People needed
- 50
- Starts
- 2025-09-30
- Expected to finish
- 2026-10-15
- Last updated by the study team
- 2025-09-16
Who can join
Age: 18 and older. Sex: female. Healthy volunteers: not accepted.
You may qualify if…
- Women aged ≥18 years.
- History of hysterectomy (any approach: abdominal, vaginal, or laparoscopic).
- Symptomatic vaginal cuff prolapse (POP-Q stage ≥ II).
- Able to provide written informed consent.
- Willing and able to comply with study procedures and follow-up visits.
You may not qualify if…
- Prior sacrocolpopexy or lateral suspension surgery.
- Active pelvic infection or untreated malignancy.
- Severe cardiopulmonary or systemic disease that contraindicates laparoscopic surgery.
- Known allergy to mesh materials used in the procedures.
- Inability to complete patient-reported questionnaires due to cognitive or language barriers.
- Concurrent pelvic organ prolapse requiring additional surgical repair beyond vaginal cuff suspension.
Where it is running
- Basaksehir Cam and Sakura City Hospital — Istanbul, Istanbul, Turkey (Türkiye) (enrolling)
Full record on ClinicalTrials.gov
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