Testing of a New Rapid Antigen Test for Plague in Ituri, Democratic Republic of the Congo.

Starting soon

Conditions studied: Plague, Bubonic; Plague, Skin, Plague, Pneumonic

In brief

This study is being done to learn more about the disease in Ituri and to evaluate a new rapid test that may help doctors find the disease more quickly. This research includes characterisation of clinical presentations and pathology of plague, as well as identification of circumstances that may increase the risk of infection. Biological samples collected include blood, mouth swab, saliva, a bubo aspirate and a sputum sample (the latter only in case of plague in the lungs). These samples will be used to test the performance of the new rapid study test.

Key facts

Study ID

NCT07174648

Run by

Institute of Tropical Medicine, Belgium

People needed

300

Starts

2026-05-01

Expected to finish

2029-01-02

Last updated by the study team

2026-03-27

Who can join

Age: 5 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• All participants (aged ≥5 year old) within Rethy, Logo and Aru health zones, presenting with possible symptoms of bubonic and/or pneumonic plague according to WHO definition
• Willing to provide voluntary consent (or voluntary assent and parental consent in case of minors.

You may not qualify if…

• Participants not eligible, able, or willing to undergo study procedures
• Children <5 years of age
• Participants on antibiotic treatment ≥48h prior to recruitment

Where it is running

• Centre De Recherche en Maladies Tropicales De L'ituri — Rethy, Democratic Republic of the Congo

Full record on ClinicalTrials.gov

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