Rocklatan Retinal Perfusion OCT Study
Starting soon · Phase 4
Conditions studied: Glaucoma
In brief
The main purpose of this study is to learn more about how Rocklatan eye drops affects blood flow in the eye. The secondary purpose is to see if our study devices can detect changes in blood flow before and after instillation of Rocklatan.
Key facts
- Study ID
- NCT07174401
- Run by
- Oregon Health and Science University
- People needed
- 30
- Starts
- 2026-01-01
- Expected to finish
- 2027-10-01
- Last updated by the study team
- 2025-12-24
Who can join
Age: 21 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients with both eyes with open angle glaucoma.
- Abnormal VF (glaucomatous pattern with PSD abnormal at p<0.05 or GHT outside normal limits) on most recent two clinic visits on chart review
- Glaucomatous disc abnormality on chart review and confirmed on baseline disc photograph
- Overall average NFL thickness > 55 μm measured by Heidelberg Spectralis OCT -Glaucoma Module Premium Edition (chart review), consistent with early glaucoma
- NFLP-CD deficit (below 5 percentile of normal) in any of the 8 sectors on the initial baseline visit
- The difference in baseline NFLP-CD between the left and right eye should be less than 5% (% of area).
- IOP >= 17 mm Hg on the most recent two clinic visits (chart review) after monotherapy with latanoprost in both eyes.
You may not qualify if…
- Best corrected visual acuity worse than 20/30 on chart review of most recent clinic visit
- Age < 21 years at baseline
- Eye disease that could affect VF, NFL thickness, or NFLP (e.g., visually significant cataract, AMD, diabetic retinopathy, and optic neuropathy) at any study visit
- OCT and OCTA scans not meeting quality criteria at baseline
- Inability to cooperate with study procedures
- Inability to commit to the study visits
Where it is running
- Casey Eye Institute - Oregon Health & Science University — Portland, Oregon, United States
Full record on ClinicalTrials.gov
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