IH, Brain Health, and T2D
Recruiting now · Not applicable · Has a placebo group
Conditions studied: Type 2 Diabetes, Aging
In brief
The purpose of this study is to use a randomized, placebo-controlled study design to rigorously examine the therapeutic potential of intermittent hypoxia (IH) for improving cerebrovascular health in older adults with and without type 2 diabetes mellitus (T2DM).
Key facts
- Study ID
- NCT07173543
- Run by
- Darren P Casey
- People needed
- 80
- Starts
- 2025-09-22
- Expected to finish
- 2028-06-30
- Last updated by the study team
- 2026-03-13
Who can join
Age: 60 and older, up to 85. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Willing and able to provide written, signed informed consent after the nature of the study has been explained, and prior to any research-related procedures.
- Age is > or = 60 and < or = 85 years of age
- Documented Type 2 diabetes
- Scoring 26 or higher on the MoCA test
You may not qualify if…
- diagnosis of type 2 diabetes < 1 year prior to enrollment
- HbA1c <6.5% or >10.0%
- body mass index > 40 kg/m 2
- incident cardiovascular events in the last year (heart attack, stroke)
- symptomatic coronary artery disease and/or heart failure
- uncontrolled hypertension
- obstructive sleep apnea
- pulmonary disease
- dementia
- renal impairment with creatinine clearance (eGFR) of <60 ml/min
- smoking or history of smoking within past one year
- 30 nondiabetic control subjects will also be studied.
- Inclusion criteria:
- Willing and able to provide written, signed informed consent after the nature of the study has been explained, and prior to any research-related procedures.
- Age is > or = 60 and < or = 85 years of age
- Scoring 26 or higher on the MoCA test
- Exclusion criteria:
- Diagnosis of diabetes (Type 1 or Type 2)
- body mass index > 40 kg/m2
- incident cardiovascular events in the last year (heart attack, stroke)
- symptomatic coronary artery disease and/or heart failure
- uncontrolled hypertension
- obstructive sleep apnea
- pulmonary disease
- dementia
Where it is running
- University of Iowa — Iowa City, Iowa, United States (enrolling)
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.