Low Level Light Therapy & Skin Pigmentation

Recruiting now · Not applicable

Conditions studied: Dry Eye, Meibomian Gland Dysfunction (Disorder)

In brief

The goal of this clinical trial is to determine if there is a difference in eyelid temperature after low-level light therapy (LLLT) in individuals with different amounts of skin pigmentation and dry eye/meibomian gland disease. Participants will have 3 fifteen minute in office LLLT therapy sessions over a period of approximately 7 to 14 days.

Key facts

Study ID

NCT07173530

Run by

University of Houston

People needed

40

Starts

2025-06-11

Expected to finish

2026-08-01

Last updated by the study team

2025-09-15

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Ability to read and understand the study informed consent in English
• Age 18 years or older at enrollment
• Individuals with MGD based on one or more of the following clinical signs/symptoms, e.g., meibum quality score of 1-3 (Bron et al.), meibography score of 1, 2, or 3 on the Pult Meiboscale, non-invasive 1st tear break up time of 10 seconds or less, or an Ocular Surface Disease Index (OSDI) score greater than 12 points.

You may not qualify if…

• Active anterior segment pathology (e.g., bacterial conjunctivitis, microbial keratitis)
• History of systemic disease associated with aqueous-deficient dry eye disease (e.g., Sjogren's syndrome)
• History of corneal surgery, refractive surgery, or eyelid surgery within 6 months
• History of corneal ectasia (e.g. keratoconus, Pellucid marginal degeneration)
• History of ocular trauma within 6 months
• History of LipiFlow, iLux, Meiboflow, IPL or LLLT within the last 12 months
• Habitual use of photosensitizing medications within the last 30 days
• Pregnant and/or lactating females, by self-report
• Pigmented lesions, tattoos, or skin cancer in the periocular region
• Unwilling to have eyes photographed or video recorded

Where it is running

• The University of Houston College of Optometry — Houston, Texas, United States (enrolling)

Full record on ClinicalTrials.gov

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