Cardiac Amyloidosis in Patients With Aortic Stenosis
Starting soon
Conditions studied: Aortic Stenosis, Transthyretin Amyloid Cardiomyopathy
In brief
This study intends to conduct a prospective observation to investigate the prevalence of cardiac amyloidosis (CA) in patients with aortic stenosis (AS), compare the clinical characteristics between patients with isolated AS and those with AS complicated by CA (CA-AS), and simultaneously explore the impact of transcatheter aortic valve replacement (TAVR) on serum transthyretin (TTR) levels in patients with AS complicated by transthyretin amyloidosis (ATTR-AS), as well as its influence on the treatment outcomes of patients with isolated AS and ATTR-AS.
Key facts
- Study ID
- NCT07170306
- Run by
- Shanghai Zhongshan Hospital
- People needed
- 143
- Starts
- 2026-01-31
- Expected to finish
- 2028-05-31
- Last updated by the study team
- 2026-01-20
Who can join
Age: 65 and older, up to 85. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Male or female patients aged ≥ 65 years and ≤ 85 years;
- Patients with moderate-to-severe degenerative aortic stenosis (AS) who are hospitalized and scheduled to undergo transcatheter aortic valve replacement (TAVR);
- Patients who voluntarily sign the Informed Consent Form (ICF) and are able to comply with the study-specified treatment plan, follow-up visits, laboratory tests, and other requirements.
You may not qualify if…
- Aortic stenosis (AS) caused by congenital diseases or rheumatic immune diseases;
- Severe renal impairment, chronic dialysis, or unresolved acute kidney injury after transcatheter aortic valve replacement (TAVR);
- Terminal-stage diseases with an expected life span of < 6 months;
- Participation in other ongoing investigational studies of drugs or medical devices that have not yet been completed;
- Patients who are unable to attend the follow-up visits scheduled in the study;
- Failure to undergo TAVR surgery, transfer to surgical treatment, or in-hospital death.
Full record on ClinicalTrials.gov
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