Aleniglipron Phase 2 Body Composition Study
Running, not enrolling · Phase 2 · Has a placebo group
Conditions studied: Obesity, Overweight, or Chronic Weight Management
In brief
This is a randomized, double-blind, placebo-controlled study evaluating the effects of aleniglipron on body composition in participants living with obesity. Participants will be randomized to aleniglipron or placebo in a ratio of 5:1. Participants will receive multiple ascending QD doses of aleniglipron or placebo in titration steps of 4 weeks duration for a total of 40 weeks of treatment.
Key facts
- Study ID
- NCT07169942
- Run by
- Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics
- People needed
- 71
- Starts
- 2025-08-15
- Expected to finish
- 2026-10-01
- Last updated by the study team
- 2026-03-03
Who can join
Age: 18 and older, up to 79. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Signed informed consent
- Participants age ≥18 years and <80 years, with BMI ≥30 kg/m2
- Screening HbA1c <6.5 %
You may not qualify if…
- Previous documented diagnosis of diabetes mellitus
- Self-reported change in body weight >5% within 3 months before Screening
- Have a body weight, height, and/or width that prohibits the ability to obtain accurate measurements according to the DXA study specific manual that allows hemi-scan
- Have a prior or planned surgical treatment for obesity (excluding liposuction or abdominoplasty, if performed >1 year prior to screening)
- Have obesity induced by other endocrine disorders (such as Cushing's syndrome, Prader-Willi syndrome, or melanocortin 4 receptor deficiency)
Where it is running
- Research Site — Phoenix, Arizona, United States
- Research Site — Chicago, Illinois, United States
- Research Site — Richfield, Minnesota, United States
- Research Site — City of Saint Peters, Missouri, United States
- Research Site — Rochester, New York, United States
- Research Site — Wilmington, North Carolina, United States
- Research Site — Norman, Oklahoma, United States
- Research Site — Moncks Corner, South Carolina, United States
- Research Site — North Charleston, South Carolina, United States
- Research Site — Austin, Texas, United States
- Research Site — San Antonio, Texas, United States
Full record on ClinicalTrials.gov
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