A Study to Evaluate LY3537021 for the Treatment of Nausea and Vomiting Caused by Chemotherapy in Adults With Cancer
Recruiting now · Phase 2 · Has a placebo group
Conditions studied: Nausea, Vomiting, Drug-Related Side Effects and Adverse Reactions, Neoplasms
In brief
The purpose of this study is to check how well LY35327021 works and how safe it is for controlling nausea and vomiting caused by chemotherapy. Participants who join this study will be in it until all parts are finished, which could take about 2 months.
Key facts
- Study ID
- NCT07169851
- Run by
- Eli Lilly and Company
- People needed
- 204
- Starts
- 2025-11-28
- Expected to finish
- 2027-02-01
- Last updated by the study team
- 2026-08-06
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Chemotherapy-naive participants, planned to receive AC or cisplatin-based chemotherapy greater than or equal to (≥)70 milligrams per square meter (mg/m²), on Day 1 of each cycle, with no multiple administrations during the CINV observation period, from Day 2 to Day 5 of each cycle.
- Have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 2.
You may not qualify if…
- Have symptomatic or untreated central nervous system (CNS) metastases.
- Have an established diagnosis of uncontrolled diabetes mellitus.
- Have a history of, or current evidence of, a clinically significant cardiac condition or QT/QTcF-related conditions.
- Have another etiology for nausea and vomiting, or receives medications with know or potential antiemetic activity
- Signs, symptoms or history of thyroid tumors
- Receives treatment with a gastric inhibitory polypetide (GIP) or glucagon-like peptide-1 (GLP-1) receptor agonist within 4 weeks prior to chemotherapy.
- Have participated in a clinical study involving study intervention within 30 days of Cycle 1 Day 1 (C1D1). If the previous study intervention has a long half-life, within 3 months or 5 halflives, whichever is longer, of C1D1.
- Are pregnant, breastfeeding, or intend to become pregnant during the study or within 30 days of the last dose of study intervention.
Where it is running
- Marin Cancer Care — Greenbrae, California, United States (enrolling)
- The First People's Hospital of Changde City — Changde, China (enrolling)
- BASS Cancer Center — Walnut Creek, California, United States (enrolling)
- City of Hope Orange County Lennar Foundation Cancer Center — Irvine, California, United States (enrolling)
- Cancer and Blood Specialty Clinic — Los Alamitos, California, United States (enrolling)
- BRCR Global - Tamarac — Tamarac, Florida, United States (enrolling)
- Summit Cancer Care, PC — Savannah, Georgia, United States (enrolling)
- Hope and Healing Cancer Services — Hinsdale, Illinois, United States (enrolling)
- UCHealth Harmony — Fort Collins, Colorado, United States (enrolling)
- North Mississippi Hematology and Oncology Associates — Tupelo, Mississippi, United States (enrolling)
- Laura and Isaac Perlmutter Cancer Center — New York, New York, United States (enrolling)
- Clavis Medical — Miami Lakes, Florida, United States (enrolling)
- Oncology Specialists of Charlotte — Charlotte, North Carolina, United States (enrolling)
- Southern Oncology Specialists — Huntersville, North Carolina, United States (enrolling)
- Asante Rogue Regional Medical Center — Medford, Oregon, United States (enrolling)
- World Research Link — Baytown, Texas, United States (enrolling)
- John Peter Smith Hospital — Fort Worth, Texas, United States (enrolling)
- Community Cancer Trials of Utah — Ogden, Utah, United States (enrolling)
- Cancer Care Northwest — Spokane, Washington, United States (enrolling)
- Ballarat Health Services — Ballarat Central, Australia (enrolling)
- Bendigo Health Care Group — Bendigo, Australia (enrolling)
- WA Country Health Service Trial Centre — Perth, Australia (enrolling)
- Goulburn Valley Health — Shepparton, Australia (enrolling)
- Latrobe Regional Health — Traralgon, Australia (enrolling)
- Zhujiang Hospital — Guangzhou, China (enrolling)
Full record on ClinicalTrials.gov
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