Observation Study on Reducing the Risk of Liver Cancer Associated With Hepatitis B (Zhiyuan) Project.

Recruiting now

Conditions studied: Chronic Hepatitis b

In brief

This study is a multicenter, prospective, observational real-world study designed to investigate and analyze the current treatment patterns of chronic hepatitis B (CHB) across 200 hospitals in China. By comparing patient outcomes under different therapeutic regimens, it aims to provide high-quality evidence-based medical data to optimize CHB treatment strategies and follow-up protocols, ultimately contributing to the advancement of a functional cure for chronic hepatitis B.

Key facts

Study ID

NCT07169656

Run by

The First Affiliated Hospital of Zhengzhou University

People needed

15000

Starts

2024-06-03

Expected to finish

2032-12-31

Last updated by the study team

2025-09-12

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 1.Chronic HBV infection (HBsAg-positive for ≥6 months); 2.Age ≥18 years; 3.Patients who, based on real-world clinical practice needs, are planned or currently receiving treatment with:Entecavir (ETV),Tenofovir disoproxil fumarate (TDF),Tenofovir alafenamide fumarate (TAF),Tenofovir amibufenamide (TMF) OR Pegylated interferon α-2b-naïve patients OR Patients re-initiating pegylated interferon α-2b therapy; 4.Written informed consent obtained from the patient.

You may not qualify if…

• 1.Severe hepatic dysfunction or decompensated cirrhosis; 2.Concurrent participation in other clinical trials; 3.Hepatocellular carcinoma (HCC).

Where it is running

• Linzhou City People's Hospital — Anyang, China (enrolling)
• Neihuang County People's Hospital — Anyang, China (enrolling)
• Tangyin County People's Hospital — Anyang, China (enrolling)
• The Fifth People's Hospital of Anyang — Anyang, China (enrolling)
• The First Affiliated Hospital of Xinxiang Medical University (Hua County Branch) — Anyang, China (enrolling)
• Guangzhou First People's Hospital — Guangzhou, China (enrolling)
• The First Affiliated Hospital of Jinan University (Guangzhou Overseas Chinese Hospital) — Guangzhou, China (enrolling)
• Hebi Coal Mining Group General Hospital — Hebi, China (enrolling)
• Hebi Infectious Disease Hospital — Hebi, China (enrolling)
• Junxian County People's Hospital — Hebi, China (enrolling)
• Bo'ai County People's Hospital — Jiaozuo, China (enrolling)
• Mengzhou Hospital of Traditional Chinese Medicine — Jiaozuo, China (enrolling)
• Qinyang People's Hospital — Jiaozuo, China (enrolling)
• The Secend People's Hospital of Jiaozuo — Jiaozuo, China (enrolling)
• The Third People's Hospital of Jiaozuo — Jiaozuo, China (enrolling)
• Xiuwu People's Hospital — Jiaozuo, China (enrolling)
• Wenxian People's Hospital — Jiayuguan, China (enrolling)
• Jiyang County Hospital of Traditional Chinese Medicine — Jinan, China (enrolling)
• Shandong Public Health Clinical Center — Jinan, China (enrolling)
• Jiyuan People's Hospital — Jiyuan, China (enrolling)
• Jiyuan Traditional Chinese Medicine Hospital — Jiyuan, China (enrolling)
• Huaihe Hospital of Henan University — Kaifeng, China (enrolling)
• Infectious Diseases Hospital of Kaifeng — Kaifeng, China (enrolling)
• Kaifeng Central Hospital — Kaifeng, China (enrolling)
• Huaxian People's Hospital — Anyang, China (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.