Steroid Treatment for Elimination of Rebound Obstruction From Intranasal Decongestants

Stopped early · Phase 2

Conditions studied: Nasal Obstruction, Chronic Rhinitis

In brief

This prospective, virtually administered trial conducted throughout the United States aims to evaluate a standardized protocol including the serial dilution of topical decongestants with concurrent topical steroids (triamcinolone), for elimination of dependence on topical decongestants.

Key facts

Study ID

NCT07168148

Run by

Washington University School of Medicine

People needed

3

Starts

2025-11-10

Expected to finish

2026-03-19

Last updated by the study team

2026-03-23

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• have a history of chronic nasal obstruction 3) at least daily topical decongestant usage for at least 3 months 4) ability to read, write, and understand English.

You may not qualify if…

• Any history of sinonasal mass/tumor
• Any history of nasal polyps
• Septal perforation
• A diagnosis of one of the following conditions:
• eosinophilic granulomatosis with polyangiitis
• granulomatosis with polyangiitis
• Any current intranasal drug use such as cocaine.
• If they are currently using or have used intranasal steroid medications (oral or nasal) besides oxymetazoline for the past month.

Where it is running

• Washington University — St Louis, Missouri, United States

Full record on ClinicalTrials.gov

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