Electrostimulation Study for Ocular Graft vs. Host Disease

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Chronic Ocular Graft-versus-host Disease

In brief

This trial is testing to see if electrostimulation treatment (ET) will be effective in treating those with ocular Graft vs. Host Disease.

Key facts

Study ID

NCT07166848

Run by

Zhonghui K. Luo, MD, PhD

People needed

15

Starts

2025-11-30

Expected to finish

2029-11-30

Last updated by the study team

2025-12-17

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of chronic ocular graft vs. host disease (oGVHD) (ICCGVHD criteria probable or definite)
• OSDI score of 22 or higher
• NEI corneal staining score (or modified NEI score) of 2 or higher.

You may not qualify if…

• Patients with any open wound on the eyelid.
• Patient with any active cornea ulcer, dacryocystitis, hordeolum, filamentary keratitis, uveitis, retinal detachment, uncontrolled glaucoma or other active pathology per PI's discretion.
• Patient with a pacemaker or ICD.
• Patient currently pregnant or with a potential to be pregnant during the study.
• Patient undergoing any ocular surgical procedure (including intravitreal injections) within the past 3 months.
• Patient undergoing any systemic surgical procedures within 2 months.
• Patient undergoing any non-surgical eyelid procedure such as punctal plugs or punctal cautery within 1 month of study initiation.
• Patients on cytotoxic agents, drugs that inhibit peripheral nerve regeneration (i.e. Gabapentin, Nicotine), radiation therapy, or any other therapy per PI's discretion.
• Patients undergoing immunosuppression regimen change within 1 month of study initiation and/or during the study period.
• Patient who wears contact lens of any kind

Where it is running

• Massachusetts Eye and Ear - Longwood Campus — Boston, Massachusetts, United States (enrolling)

Full record on ClinicalTrials.gov

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