Study to Assess the Efficacy and Safety of Rina-S Compared to Treatment of Investigator's Choice in Participants With Endometrial Cancer
Recruiting now · Phase 3
Conditions studied: Endometrial Cancer, Recurrent or Progressive Endometrial Cancer
In brief
The purpose of this study is to compare how well Rina-S (GEN1184) works compared to treatment of physician's choice (paclitaxel or doxorubicin) that are considered standard medical care for the treatment of recurrent or progressive endometrial cancer (EC) following prior therapy. There is an equal (50:50) chance of getting either Rina-S or a chemotherapy agent as treatment in this study. The study duration will be approximately 3 years. The treatment duration will be different for every participant, but an average of 4 to 6 months is expected. All participants will receive active drug; no one will be given placebo. Participation in the study will require visits to the study site(s).
Key facts
- Study ID
- NCT07166094
- Run by
- Genmab
- People needed
- 660
- Starts
- 2025-11-28
- Expected to finish
- 2029-11-01
- Last updated by the study team
- 2026-08-04
Who can join
Age: 18 and older. Sex: female. Healthy volunteers: not accepted.
Where it is running
- HonorHealth Research Inst — Phoenix, Arizona, United States (enrolling)
- Kaiser Permanente SoCal — Irvine, California, United States (enrolling)
- Norwalk Hospital — Danbury, Connecticut, United States (enrolling)
- Norwalk Hospital — Norwalk, Connecticut, United States (enrolling)
- MedStar Washington Hospital — Washington D.C., District of Columbia, United States (enrolling)
- SMH - Sarasota - Main Campus — Sarasota, Florida, United States (enrolling)
- Women's Care - 9th Ave — St. Petersburg, Florida, United States (enrolling)
- Women's Care - Armenia Ave — Tampa, Florida, United States (enrolling)
- Emory Winship Cancer Inst. — Atlanta, Georgia, United States (enrolling)
- Emory Winship Cancer Inst. — Atlanta, Georgia, United States (enrolling)
- Northside Hospital Atlanta — Atlanta, Georgia, United States (enrolling)
- Emory Winship Cancer Inst./Emory Decatur Hospital — Decatur, Georgia, United States (enrolling)
- Trials365, LLC — Shreveport, Louisiana, United States (enrolling)
- Sinai Hospital — Baltimore, Maryland, United States (enrolling)
- William Kahlert Reg. Can. Ctr — Westminster, Maryland, United States (enrolling)
- UMass Memorial Medical Ctr — Worcester, Massachusetts, United States (enrolling)
- Corewell Health — Grand Rapids, Michigan, United States (enrolling)
- USOR - Minnesota Oncology-Coon Rapids Clinic — Coon Rapids, Minnesota, United States (enrolling)
- USOR - Minnesota Oncology/ Coon Rapids Clinic — Coon Rapids, Minnesota, United States (enrolling)
- USOR - Minnesota Oncology - Edina Clinic — Edina, Minnesota, United States (enrolling)
- USOR - Minnesota Oncology/Edina Clinic — Edina, Minnesota, United States (enrolling)
- USOR - Minnesota Oncology/ Maple Grove Clinic — Maple Grove, Minnesota, United States (enrolling)
- USOR - Minnesota Oncology-Maplewood Clinic — Maplewood, Minnesota, United States (enrolling)
- USOR - Minnesota Oncology/ Maplewood Clinic — Maplewood, Minnesota, United States (enrolling)
- USAH Mitchell Cancer Inst — Mobile, Alabama, United States (enrolling)
Full record on ClinicalTrials.gov
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