The Effect of Mobilization on Inflammatory Biomarkers in Patients With Knee Osteoarthritis.

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Knee Osteoarthritis

In brief

This study is designed to investigate whether a hands-on therapy called Mobilization with Movement (MWM) can reduce pain and inflammation in individuals with knee osteoarthritis (OA). The investigators will compare MWM to a sham treatment that resembles mobilization but does not involve the specific therapeutic movements. Both groups will also receive standard care, including exercise and education about managing knee OA. A total of 40 adults (aged 18 years and older) with moderate to severe knee OA will be enrolled. Participants will be randomly assigned to either the MWM group or the sham group. Each intervention will be delivered twice per week over a four-week period. Outcomes will include measures of inflammation obtained from blood samples, self-reported pain levels, and assessments of knee function before and after the intervention period. It is hypothesized that individuals allocated to the MWM group will demonstrate reduced inflammation and pain compared with those in the sham group. The findings of this study may help clarify the potential role of MWM as a treatment option for knee OA.

Key facts

Study ID

NCT07166068

Run by

University of Jazan

People needed

40

Starts

2025-09-20

Expected to finish

2026-04-20

Last updated by the study team

2025-12-09

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Clinical diagnosis of unilateral or bilateral knee osteoarthritis (OA) according to the criteria of the American College of Rheumatology
• Age ≥ 18 years
• Kellgren-Lawrence grade 2 or 3 knee OA
• Pain intensity > 3 on a visual analogue scale (VAS)
• Body mass index (BMI) between 18.5 and 30 kg/m²

You may not qualify if…

• Knee or lower limb surgery within the last six months.
• Significant joint disorders (e.g., rheumatoid arthritis, gout, or other inflammatory arthritis).
• Recent significant acute infections.
• Contraindications to mobilization with movement.
• Current or recent use systemic glucocorticoids, intra-articular glucocorticoid injections or intra-articular hyaluronic acid injections.

Where it is running

• Jazan University Hospital — Jizan, Jazan Region, Saudi Arabia (enrolling)

Full record on ClinicalTrials.gov

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