Parent Study Name: Pulmonary Rehabilitation to Reduce Post-Tuberculosis Morbidity (TB Pure)

Recruiting now · Not applicable

Conditions studied: TB - Tuberculosis, TB, TB Infection

In brief

Individual-level, unblinded randomized controlled trial of an 8-week (short arm) or 24-week (extended arm) pulmonary rehabilitation program, relative to standard of care, to prevent post-tuberculosis respiratory morbidity. Randomization will occur in a 1:1:1 ratio at the initiation of treatment.

Key facts

Study ID

NCT07164742

Run by

Johns Hopkins University

People needed

690

Starts

2026-03-18

Expected to finish

2028-09-15

Last updated by the study team

2026-03-27

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age at least 18 years
• Microbiologically confirmed (smear microscopy, GeneXpert or culture) pulmonary TB disease*
• Not completed more than 2 weeks of TB treatment
• Receiving TB care at the outpatient clinics at the TB PuRe study sites
• Willingness to complete 48 weeks of study evaluations.
• Access to a smartphone.

You may not qualify if…

• Modified Medical Research Council score of 0 points (dyspnea only with strenuous exercise)
• Multi or extensively drug-resistant TB disease*
• Extrapulmonary TB disease at any clinical sites without pulmonary involvement
• TB meningitis or TB of the spine
• Symptomatic cardiovascular disease, including coronary artery disease, arrhythmias and congestive cardiac failure.
• Karnofsky Score < 40 points
• Any medical condition that prevents pulmonary rehabilitation eg: fracture of lower/upper limbs/pregnancy
• Bronchodilators and/or corticosteroids inhaled or otherwise.

Where it is running

• Yenepoya (Deemed to be University — Mangalore, India (enrolling)
• Symbiosis Medical College for Women & Symbiosis University Hospital and Research Center — Pune, India (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.