Azithromycin Versus Doxycycline in Hospitalized Adult Patients With Community Acquired Pneumonia Treated With Beta-lactams

Recruiting now · Phase 4

Conditions studied: Community-acquired Pneumonia

In brief

The purpose of this study is to compare effectiveness and safety of Azithromycin versus Doxycycline in adult patients hospitalized with community acquired pneumonia (CAP) treated with Beta-lactams.

Key facts

Study ID

NCT07164131

Run by

Mayo Clinic

People needed

1120

Starts

2025-09-15

Expected to finish

2031-09-01

Last updated by the study team

2026-07-02

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• All adult patients (>18 years old) admitted with CAP and receiving a beta-lactam antibiotic plus a form of atypical coverage (azithromycin or doxycycline) in the ED within 12 hours of admission.

You may not qualify if…

• High clinical suspicion for Legionella pneumonia
• Allergy or contraindication to the use of either azithromycin or doxycycline (usual clinical practice)
• Antibiotics not for CAP
• Pregnant women (based on clinical assessment as part of standard of care)
• Severe CAP as defined by the ATS/IDSA criteria
• Corrected QT prolongation (> 440 ms in men and > 460 ms in women)
• Receiving a different antibiotic (e.g quinolones)
• Admission > 24 hours
• Known to be a prisoner

Where it is running

• Mayo Clinic in Rochester — Rochester, Minnesota, United States (enrolling)
• Mayo Clinic in Arizona — Scottsdale, Arizona, United States
• Mayo Clinic in Florida — Jacksonville, Florida, United States
• Mayo Clinic Health System-Mankato — Mankato, Minnesota, United States
• Mayo Clinic Health System-La Crosse — La Crosse, Wisconsin, United States

Full record on ClinicalTrials.gov

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