Acute MI Staging Diagnosis by High-sensitivity Cardiac Troponin-I
Completed
Conditions studied: Acute Myocardial Infarction (AMI)
In brief
TROP-MI-STAGE is a multicenter retrospective diagnostic study designed to evaluate the role of high-sensitivity cardiac troponin I (hs-cTnI) in the diagnosis and clinical stage classification of acute myocardial infarction as defined by the stages of myocardial injury in CCS-AMI classification. The study retrospectively analyzes biomarker data from patients diagnosed with AMI across multiple institutions, focusing on whether hs-cTnI levels-measured at specific time points-can reliably identify and stratify patients into AMI clinical stages (Stage 1 to Stage 4). It aims to correlate hs-cTnI kinetics and peak levels with clinical stage, presentation patterns, and outcomes. This trial seeks to offer a biomarker-based alternative to imaging-heavy staging, potentially streamlining early diagnosis and therapeutic triage for AMI patients in varied clinical settings.
Key facts
- Study ID
- NCT07163988
- Run by
- Rohan Dharmakumar
- People needed
- 312
- Starts
- 2023-01-10
- Expected to finish
- 2025-09-30
- Last updated by the study team
- 2026-05-20
Who can join
Age: 18 and older, up to 79. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age 18-79 years
- Index STEMI
- Coronary angiogram with PCI to occur irrespective of the onset of the symptoms.
- Ability to provide informed consent for themselves
You may not qualify if…
- History of prior myocardial infarction,
- Cardiogenic shock,
- Patients who present with current cardiac arrest
- Any contraindication to cardiac CMR (claustrophobia, pacemaker or cardiac defibrillator, known allergy to gadolinium),
- Presence of permanent atrial fibrillation,
- Unconscious patient,
- Severe renal insufficiency (creatinine clearance ≤ 30 ml/min/m2 or renal replacement therapy),
- Women who are pregnant or breastfeeding. Women of reproductive potential must have a negative pregnancy test.
Where it is running
- Medical Imaging Research Institute — Indianapolis, Indiana, United States
Full record on ClinicalTrials.gov
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