Effect of Probiotic Intervention on Travel-Related Health Conditions During Short-Term Overseas Travel
Recruiting now · Phase 2 · Has a placebo group
Conditions studied: Healthy Adults
In brief
International travel disrupts gut health through dietary changes, microbial exposure, and stress, often causing gastrointestinal symptoms like traveler's diarrhea and sleep disturbances. These shifts may increase antibiotic resistance risks. Probiotics may help stabilize gut microbiota and improve well-being during travel. This randomized, double-blind, placebo-controlled trial investigated whether probiotic supplementation mitigates gut microbiota perturbations, gastrointestinal symptoms, and sleep issues in adults traveling abroad. The investigators also assessed changes in anxiety, well-being, gut immunity, microbial function, and antibiotic resistance genes.
Key facts
- Study ID
- NCT07163819
- Run by
- Universiti Sains Malaysia
- People needed
- 46
- Starts
- 2025-07-31
- Expected to finish
- 2025-12-31
- Last updated by the study team
- 2025-09-17
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Generally healthy adults
- Scheduled to undertake a short-term round trip (less than 7 days) to abroad
- Able to complete study procedures
- Willing to take intervention products
You may not qualify if…
- Use of antibiotics, probiotics, hormones, immunosuppressants, biologics or JAK inhibitors within four weeks prior to study
- Chronic or severe systemic diseases (including cardiovascular, hepatic, renal, malignant or psychiatric disorders)
- Uncontrolled parasitic infections
- Long-term use of corticosteroids, growth hormone, vitamin B12, lysine or inositol
- Major surgery within one month
- Allergy to probiotic components
- Other conditions deemed inappropriate by investigators
Where it is running
- Tsinghua University Science and Technology — Haidian, Beijing Municipality, China (enrolling)
- Universiti Sains Malaysia — George Town, Pulau Pinang, Malaysia
Full record on ClinicalTrials.gov
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