A Study on the Modulation of Gut Microbiota by Oral Sialic Acid in Healthy Subjects

Recruiting now · Not applicable

Conditions studied: Taking Sialic Acid to Regulate the Gut Microbiota, Healthy

In brief

This is a single-center prospective cohort study conducted by the Department of General Surgery at the Second Affiliated Hospital of Army Medical University (Xinqiao Hospital). The purpose of this study is to explore and clarify the effects of sialic acid intervention on gut microbiota structure, with a focus on the proliferation of pathogens (e.g., Escherichia coli, Klebsiella pneumoniae), and to develop novel prevention and treatment strategies for improving intestinal homeostasis.

Key facts

Study ID

NCT07162662

Run by

Xiaolong Li

People needed

42

Starts

2025-09-10

Expected to finish

2027-08-01

Last updated by the study team

2025-12-10

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Aged between 18 and 75 years
• No history of major diseases, no previous surgical history, and no history of cardiometabolic diseases (such as hypertension, diabetes mellitus, obesity, etc.)
• No use of drugs that may affect gut microbiota or metabolic function (e.g., antibiotics, probiotics, immunosuppressants, etc.);
• Voluntarily participate in the study and sign the informed consent form.

You may not qualify if…

• Comorbidities: Complicated with other severe diseases (e.g., immunodeficiency, chronic liver disease, renal insufficiency, malignant tumors, etc.).
• Recent infections: Registration records indicate a history of severe infections in the recent period (within 3 months) or currently receiving anti-infective treatment.
• Special populations: Pregnant women, lactating women, or women planning to become pregnant.
• Poor compliance: Volunteers who are unable to cooperate with the study protocol or follow-up

Where it is running

• Second Affiliated Hospital of Army Medical University — Chongqing, Chongqing Municipality, China (enrolling)

Full record on ClinicalTrials.gov

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