Phase 2a Study of VX-407 in Participants With ADPKD Who Have a Subset of PKD1 Gene Variants (AGLOW)
Running, not enrolling · Phase 2
Conditions studied: Autosomal Dominant Polycystic Kidney Disease (ADPKD)
In brief
The purpose of the study is to evaluate the effect of VX-407 on height-adjusted total kidney volume (htTKV), safety, tolerability, and pharmacokinetics (PK) of VX-407.
Key facts
- Study ID
- NCT07161037
- Run by
- Vertex Pharmaceuticals Incorporated
- People needed
- 26
- Starts
- 2025-11-19
- Expected to finish
- 2027-12-31
- Last updated by the study team
- 2026-07-30
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Alabama Kidney Research — Alabaster, Alabama, United States
- UAB Nephrology Research at CH19 — Birmingham, Alabama, United States
- Kaiser Permanente Los Angeles Medical Center — Los Angeles, California, United States
- UCSF Clinical Research Center at Parnassus — San Francisco, California, United States
- Nephrology & Hypertension Associates, PC — Middlebury, Connecticut, United States
- Yale University - Yale Nephrology Clinical Research Clinic — New Haven, Connecticut, United States
- Mayo Clinic - Jacksonville — Jacksonville, Florida, United States
- Emory School of Medicine - Renal Division — Atlanta, Georgia, United States
- Renal Associates — Columbus, Georgia, United States
- UChicago Medicine - Duchossois Center for Advanced Medicine - Nephrology — Chicago, Illinois, United States
- University of Iowa Health Care Medical Center- Nephrology — Iowa City, Iowa, United States
- Clinical & Translational Science Unit (CTSU) - Nephrology — Kansas City, Kansas, United States
- University of Maryland Medical Center - General Clinical Research Center — Baltimore, Maryland, United States
- Tufts Medical Center — Boston, Massachusetts, United States
- Beth Israel Deaconess Medical Center - Nephrology — Boston, Massachusetts, United States
- University of Minnesota -Clinics and Surgery Center (CSC) - Endocrine Clinic — Minneapolis, Minnesota, United States
- Mayo Clinic - Rochester — Rochester, Minnesota, United States
- DaVita Kidney Care - Las Vegas — Las Vegas, Nevada, United States
- The Rogosin Kidney Center — New York, New York, United States
- General Nephrology Clinic - New York City — New York, New York, United States
- Cleveland Clinic - Main Campus — Cleveland, Ohio, United States
- Geisinger Clinic — Danville, Pennsylvania, United States
- Perelman Center for Advanced Medicine - Nephrology — Philadelphia, Pennsylvania, United States
- Nephrology Clinical Trials Center — Nashville, Tennessee, United States
- UVM Medical Center - 1 South Prospect Street — Burlington, Vermont, United States
Full record on ClinicalTrials.gov
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