Obstructive Sleep Apnoea and Difficult Asthma (OSADA)

Recruiting now · Not applicable

Conditions studied: Asthma (Diagnosis), OSA - Obstructive Sleep Apnea, CPAP Treatment

In brief

The OSADA (Obstructive Sleep Apnoea in Difficult Asthma) trial is an open-label, randomized control trial investigating the impact of diagnosing and treating obstructive sleep apnoea (OSA) on a asthma control in patients with difficult-to-control asthma. Participants will undergo home-based sleep studies to assess for OSA and are then allocated to one of three arms: 1) Patients with OSA treated with CPAP (intervention group), 2) Patients with OSA not treated for OSA (control group) and 3) Patients without OSA (reference group). The primary objective is to evaluate whether treating OSA improves asthma control, symptom burden, and quality of life compared to untreated OSA and to patients without OSA. Secondary outcomes include exacerbation rates, sleep quality, and healthcare utilization. This trial aims to clarify the contribution of OSA to poor asthma control and the potential benefits of integrated sleep and respiratory care in this complex population.

Key facts

Study ID

NCT07160868

Run by

St. James's Hospital, Ireland

People needed

80

Starts

2025-09-01

Expected to finish

2026-05-22

Last updated by the study team

2026-05-26

Who can join

Age: 18 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients must have a clinical diagnosis of asthma with supportive objective diagnostics including but not limited to, variable airflow obstruction, bronchial-hyper responsiveness and demonstrable eosinophilic inflammation via fractional exhaled nitric oxide or peripheral eosinophilia
• Patients receiving step 4 or step 5 of 'The Global Initiative for Asthma' (GINA) treatment guidelines will be selected
• Between the ages of 18 to 90 years of age

You may not qualify if…

• Patients with previous sleep study investigations
• Excessive daytime sleepiness; ESS >17
• Previous diagnosis of a sleep disorder
• Resting hypoxaemia or need for long-term oxygen therapy
• Inability to provide informed consent

Where it is running

• St. James's Hospital — Dublin, Dublin, Ireland (enrolling)

Full record on ClinicalTrials.gov

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