Cognitive-Motor Training for AD/ADRD Prevention

Starting soon · Not applicable

Conditions studied: MCI, Aging

In brief

Alzheimer's disease and related dementias (AD/ADRD) greatly affect memory and daily activities in older adults. Mild Cognitive Impairment (MCI) is an early stage of dementia, affecting about 17% of older adults. People with MCI often show problems with gait and balance, which doubles their risk of falling compared to cognitively healthy peers. Falls can cause injuries, increase sedentary behavior, and reduce physical activity. This decline in activity can also speed up the progression from MCI to dementia. Exercise can help older adults make healthy lifestyle changes; however, most of the existing exercise programs focus mainly on physical movement rather than cognitive function. Therefore, the investigators developed a new program that uses computer vision and a cloud-based system to provide more scalable, engaging, and personalized cognitive-motor training for OAwMCI. The purpose of this study is to investigate the short- and long-term effects of a novel CogXergaming training (CXT) paradigm for improving the cognitive-motor function, physical activity, falls efficacy, and quality of life.

Key facts

Study ID

NCT07160582

Run by

University of Illinois at Chicago

People needed

46

Starts

2026-05-01

Expected to finish

2027-09-01

Last updated by the study team

2026-03-24

Who can join

Age: 55 and older, up to 90. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age: 55-90 years.
• No recent major surgery, bone fracture, or hospitalization (< 3 months).
• Not on any sedative drugs.
• Can understand and communicate in English.
• Can walk without an assistive device for at least 1 block to ensure independent functioning.
• Identification of Mild Cognitive Impairment (MCI) based on Jak/Bondi criteria
• Visual acuity greater than or equal to 20/40 with or without corrective lenses to ensure intact vision.

You may not qualify if…

• Participants will not proceed with the study if any of the following occurs at baseline measurement: 1) Heart Rate >85% of age-predicted maximal heart rate (HRmax) (HRmax = 220 - age), 2) systolic blood pressure (SBP) > 160 mmHg and/or diastolic blood pressure (DBP) > 110 mmHg during resting.
• Unable to stand for 5 minutes without an assistive device and walk for 10 m without an assistive device
• Complaints of shortness of breath, or uncontrolled pain (more than 3 out of 10 on Visual Analogue Scale), or if pulse oxygen drops less than 92% on the six-minute walk test (for endurance) to ensure that the participant can effectively participate without discomfort or injury during testing and training.
• Exhibits difficulty understanding the study information.
• Self-reported history or presence of any neurological, musculoskeletal, cardiorespiratory, or systemic disorders that significantly impact mobility or the ability to walk independently (without an assistive device).
• Self-reported disability (with or without an assistive device) to ensure independent functioning.
• Uncontrolled (not under any medications) hypertension to avoid cardiovascular complications during testing/training.
• Weight >220 lbs (harness weight threshold).

Where it is running

• University of Illinois at Chicago — Chicago, Illinois, United States

Full record on ClinicalTrials.gov

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