Assessing the Impact of Muvalaplin on Major Cardiovascular Events in Adults With Elevated Lipoprotein(a)

Recruiting now · Phase 3 · Has a placebo group

Conditions studied: Elevated Lp(a), Atherosclerotic Cardiovascular Disease (ASCVD)

In brief

The purpose of this study is to evaluate the efficacy of muvalaplin in reducing cardiovascular risk in participants with high lipoprotein(a) who have cardiovascular disease or are at risk of a heart attack or stroke.

Key facts

Study ID

NCT07157774

Run by

Eli Lilly and Company

People needed

10450

Starts

2025-09-02

Expected to finish

2031-03-01

Last updated by the study team

2026-08-07

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Have Lp(a) ≥175 nanomoles per liter (nmol/L)
• Meet one of the following criteria:
• Have had a prior atherosclerotic cardiovascular disease (ASCVD) event (such as heart attack, stroke, or procedure to restore blood flow to the heart or other parts of the body) within 10 years prior to screening
• Are at risk for a first ASCVD event, defined as one or more of the following:
• Documented coronary artery disease (CAD), carotid stenosis, or peripheral artery disease (PAD) without a history of ASCVD event
• A high coronary artery calcium (CAC) score
• Reduced kidney function with diabetes
• Combination(s) of high risk factors

You may not qualify if…

• Have experienced a major cardiovascular event or surgery, such as heart attack, stroke, or procedure to restore blood flow to the heart or other parts of the body, within 90 days prior to screening or occurring between screening and randomization
• Are planning or expected to undergo a procedure to restore blood flow in the arteries or a major heart surgery during the study
• Have uncontrolled high blood pressure
• Have New York Heart Association (NYHA) class III or IV heart failure
• Have undergone a procedure to remove cholesterol from the blood within 90 days of screening, or have a planned procedure during the study
• Have severe kidney impairment
• Have had cancer within 5 years prior to screening

Where it is running

• K2 MEDICAL Research THE VILLAGES — Lady Lake, Florida, United States (enrolling)
• K2 Medical Research - Maitland — Maitland, Florida, United States (enrolling)
• Soffer Health Institute — Hollywood, Florida, United States (enrolling)
• Jacksonville Center for Clinical Research — Jacksonville, Florida, United States (enrolling)
• Southwest Kidney Institute - Surprise — Surprise, Arizona, United States (enrolling)
• Prime Medical Group, LLC dba Gilbert Center for Family Medicine, LLC — Gilbert, Arizona, United States (enrolling)
• Emvera Health at Peak Phoenix — Phoenix, Arizona, United States (enrolling)
• Arrow Clinical Trials — Daytona Beach, Florida, United States (enrolling)
• John Muir Medical Center - Concord Campus — Concord, California, United States (enrolling)
• Clinical Research Institute of Arizona (CRI) - Sun City West — Sun City West, Arizona, United States (enrolling)
• Ark Clinical Research - Fountain Valley — Fountain Valley, California, United States (enrolling)
• Care Access - Huntington Beach — Huntington Beach, California, United States (enrolling)
• Pima Heart — Tucson, Arizona, United States (enrolling)
• The Cardiovascular Center — Redding, California, United States (enrolling)
• UCLA South Bay Endocrinology — Torrance, California, United States (enrolling)
• University of Colorado Anschutz Medical Campus — Aurora, Colorado, United States (enrolling)
• Legacy Clinical Trials — Colorado Springs, Colorado, United States (enrolling)
• National Heart Institute — Beverly Hills, California, United States (enrolling)
• Cardiology Associates of Fairfield County, P.C. — Stamford, Connecticut, United States (enrolling)
• Chase Medical Research, LLC — Waterbury, Connecticut, United States (enrolling)
• Excel Medical Clinical Trials — Boca Raton, Florida, United States (enrolling)
• Neighborhood Healthcare Institute of Health — Escondido, California, United States (enrolling)
• American Research Institute — Cutler Bay, Florida, United States (enrolling)
• K2 Medical Research - Daytona Beach — Daytona Beach, Florida, United States (enrolling)
• K2 Medical Research ORLANDO — Maitland, Florida, United States (enrolling)

Full record on ClinicalTrials.gov

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