Protein Supplementation and Resistance Training to Prevent Fat-Free Mass Loss Following Metabolic-Bariatric Surgery

Recruiting now · Not applicable

Conditions studied: Bariatric Surgery, Fat Free Mass

In brief

The goal of this clinical trial is to investigate the effects of daily protein supplementation and participation in a weekly supervised resistance training program on the prevention of excessive muscle mass loss following bariatric surgery. Patients treated at one of the participating centers will be invited to participate and will be randomly assigned to one of two groups. Participants in group 1 will receive standard postoperative care as currently provided. Participants in group 2 will also receive standard care, but in addition, they will be asked to consume extra protein daily and take part in a supervised resistance training session once a week. Previous research has shown that approximately one in five patients undergoing bariatric surgery experiences excessive muscle loss after the surgery. It is known that resistance training and protein intake can help maintain and even improve muscle mass. However, limited research has been conducted on the combined effects of protein supplementation and resistance training in patients after bariatric surgery. Therefore, the aim of this trial is to determine whether participants receiving the additional intervention experience less muscle mass loss compared to those receiving standard care alone.

Key facts

Study ID

NCT07156552

Run by

Radboud University Medical Center

People needed

400

Starts

2025-06-20

Expected to finish

2027-06-30

Last updated by the study team

2025-09-05

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• A scheduled metabolic-bariatric surgery (i.e. RYGB or Sleeve Gastrectomy)
• Participation in the NOK care program
• Able to understand and perform the study procedures

You may not qualify if…

• Allergic or sensitive for milk proteins, or lactose intolerant
• Diagnosed renal insufficiency
• Diagnosed intestinal diseases influencing the uptake of protein (i.e. active inflammatory bowel disease

Where it is running

• Nederlandse Obesitas Kliniek — Nieuwegein, Netherlands (enrolling)
• Nederlandse Obesitas Kliniek — Amsterdam, Netherlands

Full record on ClinicalTrials.gov

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