Persistence of Immune Response Six Years After One Dose of 9vHPV Vaccine Among Male and Female Students

Recruiting now · Phase 4

Conditions studied: HPV Vaccine

In brief

Since the 2019-2020 school year, the province of Quebec (Canada) has been administering one dose of nonavalent (9vHPV) vaccine to students of all genders in Grade 4 of elementary school through the school-based program. Little data on the immunogenicity (antibody production) and long-term efficacy of a single dose of the vaccine are available, particularly in boys. The primary objective of this study is to assess the persistence of HPV antibodies six years after the administration of a single dose of the 9vHPV vaccine to students aged 9 to 11 years in Grade 4 in 2019-2020. The study will be conducted at the CHU de Québec-Université Laval research center. Recruitment is conducted through school service centers in the Quebec City region. Youth who received only a single dose of the 9vHPV vaccine at the ages of 9-11 in 2019-2020 will be eligible to participate. Approximately 300 youth will take part in this study: 150 girls and 150 boys. Participants will have to answer few questions about their health to ensure their eligibility for the study. For eligible participants consenting to participate a 10 ml (\<1 tablespoon) blood sample will be taken.

Key facts

Study ID: NCT07156084
Run by: Canadian Immunization Research Network
People needed: 300
Starts: 2025-09-23
Expected to finish: 2026-02-01
Last updated by the study team: 2025-09-29

Who can join

Age: 15 and older, up to 17. Sex: any. Healthy volunteers: accepted.

You may qualify if…

Have received a single dose of 9vHPV vaccine at ages 9-11 during the school year 2019-2020;
Not have received any other HPV vaccine doses;
Be able to consent to the study.

You may not qualify if…

Immunosuppressed (at recruitment or when immunized).

Where it is running

Centre de recherche du CHU de Québec-Université Laval — Québec, Quebec, Canada (enrolling)

Full record on ClinicalTrials.gov

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