Study of AZD3632 Monotherapy or in Combination With Anticancer Agents in Participants With Advanced Haematologic Malignancies With KMT2Ar, NPM1m, or Other Genotypes Associated With HOX Overexpression
Recruiting now · Phase 1/Phase 2
Conditions studied: Acute Lymphoblastic Leukaemia, Acute Myeloid Leukaemia, Higher-risk Myelodysplastic Syndromes
In brief
The purpose of this study is to understand the safety, tolerability, efficacy, pharmacokinetic (PK), pharmacodynamic (PD), and preliminary efficacy of orally administered AZD3632 in participants with advanced haematologic malignancies with KMT2Ar, NPM1m, or other genotypes associated with homeobox (HOX) overexpression.
Key facts
- Study ID
- NCT07155226
- Run by
- AstraZeneca
- People needed
- 84
- Starts
- 2026-01-09
- Expected to finish
- 2029-02-15
- Last updated by the study team
- 2026-07-20
Who can join
Age: 16 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Research Site — Decatur, Illinois, United States (enrolling)
- Research Site — Bunkyō City, Japan (enrolling)
- Research Site — Okayama, Japan (enrolling)
- Research Site — Seoul, South Korea (enrolling)
- Research Site — Seoul, South Korea (enrolling)
- Research Site — Seoul, South Korea (enrolling)
- Research Site — Edinburgh, United Kingdom (enrolling)
- Research Site — London, United Kingdom (enrolling)
- Research Site — London, United Kingdom (enrolling)
- Research Site — Manchester, United Kingdom (enrolling)
- Research Site — Durham, North Carolina, United States (enrolling)
- Research Site — Houston, Texas, United States (enrolling)
- Research Site — Copenhagen, Denmark (enrolling)
- Research Site — Dresden, Germany (enrolling)
- Research Site — Frankfurt A. Main, Germany (enrolling)
- Research Site — Halle, Germany (enrolling)
- Research Site — Heidelberg, Germany (enrolling)
- Research Site — München, Germany (enrolling)
- Research Site — Ulm, Germany (enrolling)
- Research Site — Bologna, Italy (enrolling)
- Research Site — Ravenna, Italy (enrolling)
- Research Site — New York, New York, United States
- Research Site — Chapel Hill, North Carolina, United States
- Research Site — Kashiwa, Japan
- Research Site — Portland, Oregon, United States
Full record on ClinicalTrials.gov
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