Cardiac Amyloid Deposits and Heart Dysfunction in Alzheimer's Disease

Recruiting now

Conditions studied: Dementia, Alzheimer Type, Mild Cognitive Impairment, Cardiac Amyloidosis

In brief

This study seeks to explore the possible common pathogenesis of both cardiac amyloidosis and Alzheimer's disease, which can both be associated with amyloid deposits. Using Positron Emission Tomography (PET) scans with amyloid tracers - a conventional tool for non-invasively imaging amyloid deposits in Alzheimer's disease - the research will extend this imaging methodology to the heart. The study will conduct additional PET/MRI scans of the heart in patients undergoing amyloid tracer PET scans for Alzheimer's evaluations. Each participant will also undergo an echocardiogram and a clinical examination of dementia. This could potentially enhance diagnostic practices in both cardiac amyloidosis and Alzheimer's disease.

Key facts

Study ID

NCT07154394

Run by

University Hospital, Essen

People needed

15

Starts

2022-08-15

Expected to finish

2025-09-14

Last updated by the study team

2025-09-04

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients undergoing cerebral amyloid PET examination for clinical indication to clarify Alzheimer's disease
• No contraindications to undergo an MRI examination
• No contraindications to undergo an Amyloid PET scan

You may not qualify if…

• Patients with vascular dementia and confirmed other causes of dementia (e.g. stroke, vitamin deficiency, thyroid insufficiency, toxic causes such as alcohol)
• Patients with pronounced cardiac preconditions
• Pregnant and breastfeeding women

Where it is running

• University Hospital Essen — Essen, North Rhine-Westphalia, Germany (enrolling)

Full record on ClinicalTrials.gov

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