A Study to Investigate Ubamatamab With and Without REGN7075 in Adult Participants With Advanced/Metastatic Non-Small Cell Lung Cancer (NSCLC)
Recruiting now · Phase 2
Conditions studied: Advanced/Metastatic Non-Small Cell Lung Cancer
In brief
This study will evaluate two study drugs called ubamatamab and REGN7075, to see if they can help treat advanced or metastatic Non-Small Cell Lung Cancer (NSCLC), and sarilumab, to evaluate to see if it can help with immune-related side effects from ubamatamab. The study is looking at: * How well ubamatamab and REGN7075 works * The side effects that ubamatamab and REGN7075 might cause * How much ubamatamab and REGN7075 is in the blood at different times * If the body makes antibodies to ubamatamab and/or REGN7075, this may cause the ubamatamab to not work as well
Key facts
- Study ID
- NCT07154290
- Run by
- Regeneron Pharmaceuticals
- People needed
- 300
- Starts
- 2026-03-18
- Expected to finish
- 2030-06-24
- Last updated by the study team
- 2026-07-22
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Cancer Treatment Centers of America, Phoenix — Goodyear, Arizona, United States (enrolling)
- The City of Hope Orange County Lennar Foundation Cancer Center — Irvine, California, United States (enrolling)
- Rush University Medical Center — Chicago, Illinois, United States (enrolling)
- University of Illinois Chicago — Chicago, Illinois, United States (enrolling)
- Franciscan Health — Munster, Indiana, United States (enrolling)
- University of Maryland Greenebaum Comprehensive Cancer Center — Baltimore, Maryland, United States (enrolling)
- Washington University School of Medicine — St Louis, Missouri, United States (enrolling)
- University of Tennessee Medical Center — Knoxville, Tennessee, United States (enrolling)
- Sarah Cannon Research Institute — Nashville, Tennessee, United States (enrolling)
- University of Texas Medical Branch — Galveston, Texas, United States (enrolling)
- The University of Texas MD Anderson Cancer Center — Houston, Texas, United States (enrolling)
- Baylor Scott & White Health — Temple, Texas, United States (enrolling)
Full record on ClinicalTrials.gov
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