A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Osteoarthritis (OA) of the Knee
Recruiting now · Phase 3 · Has a placebo group
Conditions studied: Osteoarthritis
In brief
The GZPT master protocol will support two independent studies, J2A-MC-GZT1 and J2A-MC-GZT2. Each study will see how well and safely orforglipron works in people with obesity or overweight who have osteoarthritis (OA) of the knee with pain. Participation in the study will last about 74 weeks.
Key facts
- Study ID
- NCT07153471
- Run by
- Eli Lilly and Company
- People needed
- 800
- Starts
- 2025-09-15
- Expected to finish
- 2028-05-01
- Last updated by the study team
- 2026-08-06
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Have a body mass index (BMI) of 27 kilograms per square meter (kg/m2) or higher at screening
- Have tried at least once to lose weight through diet but were unsuccessful
- Have osteoarthritis of the knee and at least one of the following conditions:
- Be over 50 years old
- Have morning knee stiffness that lasts about 30 minutes
- Have a crackling or grinding sound or feeling in the knee
You may not qualify if…
- Have gained or lost more than 11 pounds within 90 days prior to screening
- Have had a surgery for obesity or plan to have one in the next 18 months
- Have an active knee infection
- Have type 1 diabetes, type 2 diabetes, or any other type of diabetes
- Have had a recent heart condition or New York Heart Association Functional Classification Class IV congestive heart failure
- Have used any glucagon-like peptide-1 (GLP-1) receptor agonist medication within 180 days of screening
Where it is running
- AMR Clinical — Tempe, Arizona, United States (enrolling)
- Care Access - Huntington Beach — Huntington Beach, California, United States (enrolling)
- Care Access - Thousand Oaks — Thousand Oaks, California, United States (enrolling)
- Legacy Clinical Trials — Colorado Springs, Colorado, United States (enrolling)
- Chase Medical Research, LLC — Waterbury, Connecticut, United States (enrolling)
- Care Access - Decatur — Decatur, Georgia, United States (enrolling)
- North Georgia Clinical Research — Woodstock, Georgia, United States (enrolling)
- Northwestern University — Chicago, Illinois, United States (enrolling)
- AMR Clinical — Newton, Kansas, United States (enrolling)
- MedVadis Research Corporation — Waltham, Massachusetts, United States (enrolling)
- StudyMetrix Research — City of Saint Peters, Missouri, United States (enrolling)
- AMR Clinical — Kansas City, Missouri, United States (enrolling)
- Cardio Metabolic Institute — Somerset, New Jersey, United States (enrolling)
- Carolina Research Center — Shelby, North Carolina, United States (enrolling)
- University Orthopedics Center — Altoona, Pennsylvania, United States (enrolling)
- Care Access - Rapid City — Rapid City, South Dakota, United States (enrolling)
- AMR Clinical — Knoxville, Tennessee, United States (enrolling)
- Mercy Family Clinic — Dallas, Texas, United States (enrolling)
- Juno Research — Houston, Texas, United States (enrolling)
- Biopharma Informatic, LLC — Houston, Texas, United States (enrolling)
- Activian Clinical Research — Kingwood, Texas, United States (enrolling)
- Advanced Rheumatology of Houston - Woodlands — The Woodlands, Texas, United States (enrolling)
- Charlottesville Medical Research — Charlottesville, Virginia, United States (enrolling)
- Gershon Pain Specialists — Virginia Beach, Virginia, United States (enrolling)
- Arizona Research Center — Phoenix, Arizona, United States (enrolling)
Full record on ClinicalTrials.gov
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