Efficacy of Bee Venom Phonophoresis in Treating Chronic Sinusitis:
Starting soon · Not applicable
Conditions studied: Chronic Sinusitis, Acute Sinusitis, Rhinosinusitis
In brief
This double-blind, randomized controlled trial (BEE-SONIC) aims to evaluate the efficacy of bee venom phonophoresis in the treatment of chronic sinusitis. Thirty adult patients (aged 18-65 years) with clinically diagnosed chronic or acute sinusitis will be randomized into two groups: the intervention group will receive bee venom phonophoresis using low-to-moderate intensity ultrasound, while the control group will receive standard care consisting of oral decongestants and saline nasal irrigation. Primary outcomes include improvement in symptom severity (SNOT-22, Visual Analog Scale) and quality of life (SF-33). Secondary outcomes include reduction in facial pain, nasal congestion, and patient satisfaction. Data will be collected at baseline, midpoint, and post-intervention, and analyzed using paired t-tests and ANOVA. The study has received ethics approval from Sinai University's Human Research Ethics Committee, and informed consent will be obtained from all participants.
Key facts
- Study ID
- NCT07151313
- Run by
- Sinai University
- People needed
- 30
- Starts
- 2026-08-15
- Expected to finish
- 2027-12-25
- Last updated by the study team
- 2026-08-04
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Adults aged 18 to 65 years.
- Clinical diagnosis of chronic sinusitis (symptoms ≥ 12 weeks) or acute sinusitis confirmed by an otolaryngologist.
- Willing and able to provide written informed consent.
You may not qualify if…
- Known allergy or hypersensitivity to bee venom or bee products.
- Skin conditions (e.g., eczema, dermatitis, open wounds) over the area of ultrasound application.
- Severe comorbid medical conditions (e.g., uncontrolled asthma, autoimmune disease, malignancy).
- Pregnancy or breastfeeding.
- Use of systemic corticosteroids, antibiotics, or other medications that may significantly alter sinusitis symptoms within 4 weeks prior to enrollment.
- Participation in another clinical trial within the past 30 days.
Where it is running
- Sinai university — Cairo, Egypt
Full record on ClinicalTrials.gov
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