Wildfire Related Air Pollution Exposure and Cognitive Function Pilot Study
Completed · Not applicable
Conditions studied: Healthy Participants
In brief
This study will examine how breathing wildfire-related air pollution (WRAP) for one hour affects healthy adults. The main question the study will answer if the effect of WRAP exposure on p-tau, a blood marker of cognitive decline. The changes in p-tau concentrations after exposure to WRAP will be compared to the changes in p-tau after exposure to clean air. Participants will: * Have 2 study visits - one visit with exposure to clean air and one visit with exposure to simulated wildfire smoke * Have blood drawn before and after each exposure * Complete cognitive tests and memory tasks before and after each exposure
Key facts
- Study ID
- NCT07151235
- Run by
- Rutgers, The State University of New Jersey
- People needed
- 12
- Starts
- 2025-09-18
- Expected to finish
- 2025-11-20
- Last updated by the study team
- 2025-12-02
Who can join
Age: 18 and older, up to 40. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Healthy
- Non smoker
- Weight at least 110 pounds
- Between ages 18 and 40 years old
You may not qualify if…
- Claustrophobia or not comfortable in enclosed spaces.
- Colorblindness.
- Inability to hear verbal instructions.
- Cardiovascular disease which, in the opinion of the investigator, would elevate the participant's risk of adverse effects to WRAP exposure. This includes a history of stroke.
- Diabetes requiring the use of insulin.
- Pregnancy (A pregnancy test will be provided to you).
- Current asthma (an asthma attack within the past five years).
- History of childhood asthma.
- Medications which may affect cognition such as beta-blockers and CNS depressants.
- Respiratory symptoms in the previous 4 weeks (cough, wheezing, shortness of breath, etc.) which, in the opinion of the investigator, would elevate the participant's risk of adverse effects to WRAP exposure.
- Use of sedating cold/allergy medications in the previous week.
- Use of marijuana in the previous week.
- Consumption of alcohol in the previous 24 hours.
- Kidney or liver disease.
- Thyroid disease.
- High blood pressure.
- Cancer.
- Parkinson's disease.
- Pacemaker.
- Hay fever.
Where it is running
- Rutgers-EOHSI — Piscataway, New Jersey, United States
Full record on ClinicalTrials.gov
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