Short Course Radiotherapy

Recruiting now · Not applicable

Conditions studied: Central Nervous System Cancer

In brief

This is a single arm prospective pilot trial determining the safety of short-course radiation therapy in pediatric patients with incurable central nervous system malignancies.

Key facts

Study ID

NCT07147179

Run by

Abramson Cancer Center at Penn Medicine

People needed

15

Starts

2026-04-02

Expected to finish

2027-03-01

Last updated by the study team

2026-05-05

Who can join

Age: any, up to 21. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male or female, aged 21 years or below
• Lansky performance status >= 40
• Has a diagnosis of an incurable malignancy that:
• Originates outside the brain but is metastatic to 1 or more sites within the brain, or originates and recurs within the brain. For this diagnosis to be confirmed, there must be multidisciplinary review of up to date imaging at a pediatric tumor board with unanimous consensus of intracranial relapse or metastasis. If the consensus is not unanimous, short-interval repeat imaging with subsequent unanimous consensus would be required in order for this eligibility criteria to be met
• Has at least 1 targetable intracranial lesion as seen on imaging
• Has a multidisciplinary consensus recommendation for palliative intent radiation
• Consents to the study or has caregiver who is able to provide signed and dated informed consent. For subjects under the age of 18, a signed and dated assent form as able.
• Patients who had prior radiation in planned treatment area are also eligible to enter the trial
• Stated willingness to comply with all study procedures and availability for the duration of the study

You may not qualify if…

• Radiotherapy for curative intent
• Serious uncontrolled systemic or psychiatric disorders that would interfere with participation in the protocol
• Being planned for proton radiation

Where it is running

• University of Pennsylvania — Philadelphia, Pennsylvania, United States (enrolling)

Full record on ClinicalTrials.gov

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